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Articles Published Processes
11/28/2025 3:10:34 AM | Browse: 4 | Download: 18
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Received |
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2025-09-18 03:11 |
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Peer-Review Started |
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2025-09-18 03:12 |
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To Make the First Decision |
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Return for Revision |
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2025-09-30 09:52 |
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Revised |
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2025-09-30 13:15 |
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Second Decision |
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2025-10-22 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-22 03:00 |
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Articles in Press |
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2025-10-22 03:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-10-26 17:21 |
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Typeset the Manuscript |
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2025-11-21 01:31 |
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Publish the Manuscript Online |
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2025-11-28 03:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anna Smirnova, Daria Eygel, Irina Kondrasheva, Denis S Baranovskii and Ilya D Klabukov |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Science Foundation |
24-64-00028 |
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| Corresponding Author |
Ilya D Klabukov, Director, PhD, Department of Regenerative Medicine, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, No. 4 Koroleva Street, Obninsk 249036, Russia. ilya.klabukov@gmail.com |
| Key Words |
Cancer; Cell death; Colorectal cancer; Extracellular matrix; Mechanotransduction; mRNA therapy; Programmed cell death; Pyroptosis; Tumor microenvironment |
| Core Tip |
The molecular patterns of the special types of the programmed cell death, such as apoptosis, pyroptosis, ferroptosis and necroptosis, in cancer cells caused by the altered regulation, could improve the effectiveness of the mRNA vaccines and targeted therapies by overcoming the barrier function of the tumor microenvironment. Activation of specific pathways to overcome the barrier function in cancer treatment represents a promising strategy for targeted cellular and gene therapies, as well as for enhancing radiosensitivity in radiation therapy. |
| Publish Date |
2025-11-28 03:10 |
| Citation |
<p>Smirnova A, Eygel D, Kondrasheva I, Baranovskii DS, Klabukov ID. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms. <i>World J Gastroenterol</i> 2025; 31(44): 114404</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i44/114404.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i44.114404 |
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