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Articles Published Processes
2/27/2026 8:35:12 AM | Browse: 39 | Download: 170
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Received |
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2025-09-19 07:26 |
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Peer-Review Started |
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2025-09-19 07:26 |
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First Decision by Editorial Office Director |
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2025-11-14 09:14 |
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Return for Revision |
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2025-11-14 09:14 |
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Revised |
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2025-11-18 02:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-04 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 11:36 |
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Articles in Press |
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2026-01-04 11:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-09 00:51 |
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Publish the Manuscript Online |
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2026-02-27 08:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
He-Rui Wei and Fan Xiao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fan Xiao, PhD, Beijing Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. xiaofan@ccmu.edu.cn |
| Key Words |
Cholelithiasis; Succinylation; Lysine acetyltransferase 2A; Adenosine monophosphate-activated protein kinase; Protein post-translational modification |
| Core Tip |
While the role of lysine succinylation, a significant post-translational modification, remains largely unexplored in the context of cholelithiasis, this investigation demonstrates that lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses cholelithiasis through modulation of the adenosine monophosphate-activated protein kinase/sirtuin 1 signaling axis, thereby attenuating inflammatory responses. These findings offer a transformative understanding of cholelithiasis pathogenesis and establish protein succinylation as a promising therapeutic target, effectively addressing a critical research void in this field. |
| Publish Date |
2026-02-27 08:35 |
| Citation |
Wei HR, Xiao F. Succinylation: A novel regulatory axis in cholelithiasis-insights from lysine acetyltransferase 2A/adenosine monophosphate-activated protein kinase signaling. World J Gastroenterol 2026; 32(9): 114416
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i9/114416.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i9.114416 |
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