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Articles Published Processes
5/28/2026 8:52:31 AM | Browse: 2 | Download: 0
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Received |
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2025-09-23 07:43 |
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Peer-Review Started |
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2025-09-23 07:44 |
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First Decision by Editorial Office Director |
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2025-10-24 11:13 |
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Return for Revision |
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2025-10-26 14:47 |
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Revised |
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2025-11-14 16:03 |
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Publication Fee Transferred |
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2025-11-18 08:03 |
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Second Decision by Editor |
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2026-02-02 02:56 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-02 05:43 |
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Articles in Press |
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2026-02-02 05:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-16 03:31 |
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Publish the Manuscript Online |
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2026-05-28 08:52 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Zhong, Wei Chen, Sen Li, Dong-Lin Zheng, Yi-Dan Wang, Jia-Hui Huang, Xing-Qiu Liang and Ming-Kun Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation |
No. 81960807 |
| Guangxi Natural Science Foundation |
No. 2023GXNSFAA026237 |
| Guangxi Xinglin Young Talents Project of Guangxi University of Traditional Chinese medicine |
No. 2022C026 and No. 2022C042 |
| Guangxi Zhuang Autonomous Region’s First Batch of Medical Young Reserve Talent Training Program |
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| Corresponding Author |
Xing-Qiu Liang, PhD, Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 530011, Guangxi Zhuang Autonomous Region, China. 121308213@qq.com |
| Key Words |
Guipi pill; Depression; Gut-brain axis; Traditional Chinese medicine; Immune regulation; Transcriptomics; Granzyme A; Chronic unpredictable mild stress; Inflammatory bowel disease; Expression quantitative trait loci |
| Core Tip |
This study demonstrates that the traditional formula Guipi pill (GPP) alleviates depression by modulating the gut-brain axis via immune regulation. GPP significantly improved depressive-like behaviors in a chronic unpredictable mild stress rat model and altered the expression of 1349 genes, with GZMA playing a key role. Mechanistically, GPP enhanced GZMA expression in CD8+ T-cell subsets, promoting effector T cells while reducing naïve T cells. These results suggest a novel immune-mediated pathway for GPP’s antidepressant effect. |
| Publish Date |
2026-05-28 08:52 |
| Citation |
Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i6/114553.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i6.114553 |
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