| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Ding, Chu-Ye Wang, Ya-Ting Pan, Yu-Jia Wang, Ai-Guang Zhao and Hong-Zhu Wen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82374200 |
| Construction of Traditional Chinese Medicine Inheritance and Innovation Development Demonstration Pilot Projects in Pudong New Area - High-Level Research-Oriented Traditional Chinese Medicine Hospital Construction |
YC-2023-0901 |
|
| Corresponding Author |
Hong-Zhu Wen, Department of Gastroenterology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping Road, Shanghai 200032, China. ellawhz@sina.com |
| Key Words |
Ulcerative colitis; Scutellaria baicalensis Georgi; Mechanism of action; Clinical trials; Traditional Chinese medicine therapy |
| Core Tip |
As a traditional Chinese medicine, Scutellaria baicalensis Georgi (HQ) plays a crucial role in the treatment of ulcerative colitis (UC) since it contains multiple active components, such as baicalein, wogonin, baicalin, wogonoside and polysaccharides. HQ exerts therapeutic efficacy in UC through multiple mechanisms, including modulation of pro- and anti-inflammatory cytokine expression, regulation of immune cell function, protection of the intestinal barrier, and exertion of antioxidant and anti-apoptotic activities, as well as modulation of the gut microbiota. Clinically, HQ-based formulations, either used alone or in combination with conventional Western medications, have demonstrated favorable outcomes in UC management, such as reducing adverse drug reactions, enhancing therapeutic efficacy, and lowering recurrence rates. |
| Publish Date |
2026-01-05 03:46 |
| Citation |
Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i1/114558.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i1.114558 |
