Publication Name	World Journal of Gastroenterology
Manuscript ID	11456
Country	United States

Received	2014-05-22 08:52
Peer-Review Started	2014-05-22 13:36
To Make the First Decision	2014-06-10 13:23
Return for Revision	2014-06-18 13:52
Revised	2014-07-11 02:36
Second Decision	2014-07-25 09:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:38
Articles in Press	2014-07-25 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-26 07:08
Typeset the Manuscript	2014-11-11 13:30
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection
Manuscript Source	Unsolicited Manuscript
All Author List	Kaartik Soota and Benedict Maliakkal
Funding Agency and Grant Number
Corresponding Author	Benedict Maliakkal, MD, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, United States. benedict_maliakkal@urmc.rochester.edu
Key Words	Chronic hepatitis C; Therapy; Ribavirin; Hemolysis; Heme oxygenase-1
Core Tip	Innate immune tolerance leads to chronic hepatitis C virus (cHCV) infection as a pro-inflammatory state develops within the liver. The suppression of heme oxygenase-1 (HMOX1) by HCV plays a major role in perpetuating the infection and inflammation. Ribavirin (RBV) therapy, which increases heme delivery to the liver, can overcome this inhibition. HMOX1 induction in Kupffer cells reduces the pro-inflammatory state produced by HCV, whereas HMOX1 induction in hepatocytes decreases viral multiplication and apoptosis. HMOX1-induced hemolysis in the liver results in higher sustained viral response rates when RBV is used with interferon in the treatment of cHCV.
Publish Date	2014-11-20 20:51
Citation	Soota K, Maliakkal B. Ribavirin induced hemolysis: A novel mechanism of action against chronic hepatitis C virus infection. World J Gastroenterol 2014; 20(43): 16184-16190
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16184.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16184

Full Article (PDF)	WJG-20-16184.pdf
Full Article (Word)	WJG-20-16184.doc
Manuscript File	11456-Review.docx
Answering Reviewers	11456-Answering reviewers.pdf
Copyright License Agreement	11456-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11456-Language certificate.pdf
Peer-review Report	11456-Peer reviews.pdf
Scientific Misconduct Check	11456-CrossCheck.jpg
Scientific Editor Work List	11456-Scientific editor work list.pdf