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Articles Published Processes
1/22/2026 8:14:06 AM | Browse: 0 | Download: 0
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Received |
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2025-09-23 05:59 |
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Peer-Review Started |
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2025-09-23 06:00 |
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First Decision by Editorial Office Director |
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2025-10-23 08:58 |
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Return for Revision |
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2025-10-23 08:58 |
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Revised |
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2025-11-04 22:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-02 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-03 04:01 |
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Articles in Press |
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2025-12-03 04:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-15 01:13 |
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Publish the Manuscript Online |
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2026-01-22 08:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kalinne Kelly Lima Gadelha, Armênio Aguiar Santos, Paulo Correia-de-Sá, Pedro Jorge Caldas Magalhães and Moisés Tolentino Bento da Silva |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Moisés Tolentino Bento da Silva, Assistant Professor, Laboratory of Physiology, Department of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Science, Center for Drug Discovery and Innovative Medicines/RISE-Health: Health Research Network, University of Porto, No. 228 Jorge Viterbo Ferreira Street, Porto 4050-313, Portugal. mtsilva@icbas.up.pt |
| Key Words |
Gastroesophageal reflux disease; Oesophageal motility; Bile acids and salts; Barrett’s oesophagus; G-protein-coupled bile acid receptor |
| Core Tip |
Gastroesophageal reflux disease is characterised by the retrograde flow of gastroduodenal contents into the oesophagus. Although its pathophysiology is not fully understood, it is recognised to evolve into different forms of varying severity, including Barrett’s oesophagus and oesophageal adenocarcinoma. Impaired oesophageal motility, often characterised as hypomotility, is a primary factor contributing to the disease’s development. Studies suggest that the liver-synthesized bile salts, which are duodenal components found in the reflux material, may be directly involved in this dysfunction. Therefore, more in-depth investigations are needed to fully understand gastroesophageal reflux disease’s pathophysiology and the influence of bile salts on oesophageal dysmotility, as well as potential signalling pathways. |
| Publish Date |
2026-01-22 08:14 |
| Citation |
Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i4/114560.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i4.114560 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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