BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/8/2026 7:28:50 AM | Browse: 16 | Download: 109
 |
Received |
|
2025-09-23 06:54 |
|
Peer-Review Started |
|
2025-09-23 06:56 |
|
First Decision by Editorial Office Director |
|
2025-11-24 12:42 |
|
Return for Revision |
|
2025-11-24 12:50 |
|
Revised |
|
2025-12-01 15:02 |
|
Publication Fee Transferred |
|
2025-12-06 12:18 |
|
Second Decision by Editor |
|
2026-01-13 02:34 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-14 07:19 |
|
Articles in Press |
|
2026-01-14 07:19 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-01-29 09:10 |
|
Publish the Manuscript Online |
|
2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer?
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Kai Wen, Jing Xia, Lu Yu, Guo-Liang Xu, Gang-Fu Ye and Yu-Hua Lin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xiamen Health Commission High-Quality Development Science and Technology Plan Project |
2024GZL-GG49 |
| Fujian Province Natural Science Foundation Project |
2024J01320307 |
| Fujian Provincial Health Commission Youth Research Project |
2024QNB021 |
| National Natural Science Foundation of China (Youth) Program |
82405349 |
|
| Corresponding Author |
Yu-Hua Lin, PhD, Department of Respiratory Medicine, Xiamen Traditional Chinese Medicine Hospital Affiliated to Fujian University of Traditional Chinese Medicine, No. 1739, Xianyue Road, Xiamen 361015, Fujian Province, China. lin1083885768@163.com |
| Key Words |
Clinical translation; Cell signal transduction; Colorectal cancer; Hepatocyte growth factor; Cellular-mesenchymal epithelial transition factor |
| Core Tip |
This comprehensive review delineates the complex cellular-mesenchymal epithelial transition factor (c-Met)/hepatocyte growth factor signaling network as a central driver of colorectal cancer progression, metastasis, and resistance to epidermal growth factor receptor-targeted therapies. We highlight innovative insights, including the distinct tumor-suppressive roles of microRNA-1 and microRNA-137 in regulating c-Met, the critical function of the transcriptional activator metastasis associated in colon cancer 1, and the pathway’s extensive crosstalk with vascular endothelial growth factor and insulin-like growth factor-1 receptor. The review synthesizes recent advances in c-Met-targeted agents (inhibitors and monoclonal antibodies) and emerging non-invasive molecular imaging techniques. It proposes novel, biomarker-driven combination strategies and patient stratification approaches to overcome therapeutic resistance, paving the way for personalized treatment in colorectal cancer. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Wen JK, Xia J, Yu L, Xu GL, Ye GF, Lin YH. Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer? World J Gastrointest Oncol 2026; 18(4): 114567 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/114567.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.114567 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
