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Articles Published Processes
4/8/2026 7:28:50 AM | Browse: 1 | Download: 0
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Received |
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2025-09-23 06:54 |
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Peer-Review Started |
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2025-09-23 06:56 |
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First Decision by Editorial Office Director |
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2025-11-24 12:42 |
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Return for Revision |
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2025-11-24 12:50 |
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Revised |
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2025-12-01 15:02 |
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Publication Fee Transferred |
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2025-12-06 12:18 |
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Second Decision by Editor |
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2026-01-13 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-14 07:19 |
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Articles in Press |
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2026-01-14 07:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-29 09:10 |
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Publish the Manuscript Online |
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2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Kai Wen, Jing Xia, Lu Yu, Guo-Liang Xu, Gang-Fu Ye and Yu-Hua Lin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xiamen Health Commission High-Quality Development Science and Technology Plan Project |
2024GZL-GG49 |
| Fujian Province Natural Science Foundation Project |
2024J01320307 |
| Fujian Provincial Health Commission Youth Research Project |
2024QNB021 |
| National Natural Science Foundation of China (Youth) Program |
82405349 |
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| Corresponding Author |
Yu-Hua Lin, PhD, Department of Respiratory Medicine, Xiamen Traditional Chinese Medicine Hospital Affiliated to Fujian University of Traditional Chinese Medicine, No. 1739, Xianyue Road, Xiamen 361015, Fujian Province, China. lin1083885768@163.com |
| Key Words |
Clinical translation; Cell signal transduction; Colorectal cancer; Hepatocyte growth factor; Cellular-mesenchymal epithelial transition factor |
| Core Tip |
This comprehensive review delineates the complex cellular-mesenchymal epithelial transition factor (c-Met)/hepatocyte growth factor signaling network as a central driver of colorectal cancer progression, metastasis, and resistance to epidermal growth factor receptor-targeted therapies. We highlight innovative insights, including the distinct tumor-suppressive roles of microRNA-1 and microRNA-137 in regulating c-Met, the critical function of the transcriptional activator metastasis associated in colon cancer 1, and the pathway’s extensive crosstalk with vascular endothelial growth factor and insulin-like growth factor-1 receptor. The review synthesizes recent advances in c-Met-targeted agents (inhibitors and monoclonal antibodies) and emerging non-invasive molecular imaging techniques. It proposes novel, biomarker-driven combination strategies and patient stratification approaches to overcome therapeutic resistance, paving the way for personalized treatment in colorectal cancer. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Wen JK, Xia J, Yu L, Xu GL, Ye GF, Lin YH. Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer? World J Gastrointest Oncol 2026; 18(4): 114567 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/114567.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.114567 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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