| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Irfan F Corovic, Jelena M Pantic, Isidora A Stanisavljevic, Sladjana M Pavlovic, Ivan P Jovanovic, Gordana D Radosavljevic and Bojana J Simovic Markovic |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Junior Projects of the Faculty of Medical Sciences, University of Kragujevac, Serbia |
JP06/23 |
| the Ministry of Science, Technological Development and Innovation of the Republic of Serbia |
451-03-137/2025-03/200111 |
|
| Corresponding Author |
Bojana J Simovic Markovic, Associate Professor, Senior Scientist, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovic 69, Kragujevac 34000, Serbia. bojana.simovic@gmail.com |
| Key Words |
Interleukin-33/suppression of tumorigenicity 2 axis; Acute gastric injury; Nuclear factor kappa B; NOD-like receptor family, pyrin domain containing 3 inflammasome; Cell death; Peptic ulcer; Interleukin 33 |
| Core Tip |
Our study shows that suppression of tumorigenicity 2 deletion markedly reduces acute gastric mucosal injury by limiting nuclear factor kappa B and NOD-like receptor family, pyrin domain containing 3 inflammatory signaling, and subsequently immune cell infiltration, proinflammatory cytokine secretion, as well as epithelial cell death. These findings provide mechanistic insight into how interleukin-33/suppression of tumorigenicity 2 drives gastric mucosal damage and highlight this pathway as a potential therapeutic target in acute gastric injury. |
| Publish Date |
2026-03-19 07:07 |
| Citation |
Corovic IF, Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, Radosavljevic GD, Simovic Markovic BJ. ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death. World J Gastroenterol 2026; 32(12): 114576 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i12/114576.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i12.114576 |
