| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Er-Li Gu, Yi-Qi Yu, Jia-Li Wang, Yan-Yan Ji, Xiu-Yun Ma, Qing Xie, Hong-Ying Pan, Shan-Min Wu, Jun Li, Cheng-Wei Chen, Xiao-Wei Xu, Yue-Er Wang, Guang-Bi Yao, Hong Wang and Wen-Hong Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Medical Specialties Fund of Shanghai Municipal Health Bureau |
05II 011 2-1(partially) |
| GlaxoSmithKline (China) Investment Co, Ltd |
110353 |
|
| Corresponding Author |
Hong Wang, MD, Department of Gastroenterology and Hepatology, Jing’an District Central Hospital, Jing’an Branch of Huashan Hospital, Fudan University, No. 259 Xikang Road, Shanghai 200040, China. wanghongjzx@aliyun.com |
| Key Words |
Hepatitis B; Cirrhosis; Adefovir dipivoxil; Lamivudine; Response-guided therapy |
| Core Tip |
We conducted this prospective cohort study to explore an optimized strategy of adding adefovir (ADV) and lamivudine (LAM) at different time points according to the early virological response, and to observe its association with long-term treatment outcomes in cirrhotic hepatitis B (CHB) patients with compensated cirrhosis. We found that optimized response-guided add-on therapy of ADV and LAM maintains long-term suppression of hepatitis B virus DNA and improves liver function in CHB patients with compensated liver cirrhosis. |
| Publish Date |
2015-01-18 16:09 |
| Citation |
Gu EL, Yu YQ, Wang JL, Ji YY, Ma XY, Xie Q, Pan HY, Wu SM, Li J, Chen CW, Xu XW, Wang YE, Yao GB, Wang H, Zhang WH. Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study. World J Gastroenterol 2015; 21(2): 653-660 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i2/653.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i2.653 |
