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Articles Published Processes
2/6/2026 6:30:40 AM | Browse: 2 | Download: 10
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Received |
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2025-09-24 02:12 |
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Peer-Review Started |
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2025-09-24 02:12 |
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First Decision by Editorial Office Director |
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2025-10-10 08:57 |
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Return for Revision |
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2025-10-10 08:57 |
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Revised |
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2025-10-11 12:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-18 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-18 11:11 |
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Articles in Press |
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2025-12-18 11:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-29 10:18 |
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Publish the Manuscript Online |
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2026-02-06 06:30 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Asmaa M Hasan, Sara M F I Ghanem, Amira A A Othman, Mai Hamdy Rashad, Nahla Nosair and Rasha Elgamal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Amira A A Othman, Department of Internal Medicine, Faculty of Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg |
| Key Words |
Hepatocellular carcinoma; Hepatitis C virus infection; Immune checkpoints; Programmed death 1 receptor; T-cell immunoglobulin and ITIM domain; T-cell immunoglobulin and mucin-domain containing protein 3 |
| Core Tip |
Hepatocellular carcinoma linked to hepatitis C virus (HCV) is a major health burden in Egypt. This study comprehensively evaluated T cell exhaustion markers, programmed death 1, T cell immunoglobulin and ITIM domain, and T cell immunoglobulin and mucin domain-containing protein 3, on CD4+ and CD8+ T cells across HCV-related liver disease stages. Using advanced analyses, including Random Forest modeling, Cox regression, and mediation analysis, we identified CD4 programmed death 1 and CD8/T cell immunoglobulin and mucin domain-containing protein 3 as robust prognostic biomarkers of poor survival. These findings highlight novel immune targets for risk stratification and potential immunotherapy in HCV-related hepatocellular carcinoma. |
| Publish Date |
2026-02-06 06:30 |
| Citation |
Hasan AM, Ghanem SMFI, Othman AAA, Rashad MH, Nosair N, Elgamal R. T cell exhaustion markers in hepatitis C virus-related hepatocellular carcinoma: Expression patterns and prognostic significance in an Egyptian cohort. World J Clin Oncol 2026; 17(2): 114622 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i2/114622.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i2.114622 |
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