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Articles Published Processes
12/25/2025 8:27:23 AM | Browse: 0 | Download: 0
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Received |
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2025-09-24 09:03 |
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Peer-Review Started |
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2025-09-24 09:03 |
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First Decision by Editorial Office Director |
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2025-09-29 07:04 |
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Return for Revision |
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2025-09-29 07:04 |
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Revised |
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2025-10-01 10:42 |
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Publication Fee Transferred |
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2025-10-06 15:08 |
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Second Decision by Editor |
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2025-11-03 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-03 07:03 |
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Articles in Press |
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2025-11-03 07:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-11 23:51 |
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Publish the Manuscript Online |
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2025-12-25 08:27 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Dexmedetomidine enhances recovery after gastrointestinal cancer surgery by protecting the endothelial glycocalyx: A randomized, double-blind, placebo-controlled study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rong Zeng, Chao-Liang Tang, Yue Zhao, Rui-Xiang Wang, Yun Fang and Xian-Wen Hu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xian-Wen Hu, PhD, Department of Anaesthesiology, Second Affiliated Hospital Of Anhui Medical University, Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Number 678 of Fu Rong Road, Hefei ,China, Hefei 230601, Anhui Province, China. huxianwen001@163.com |
| Key Words |
Dexmedetomidine; Vascular endothelial glycocalyx; Syndecan-1; Surgical inflammation; Gastrointestinal neoplasms |
| Core Tip |
This randomized controlled trial demonstrates that perioperative dexmedetomidine (DEX) infusion attenuates vascular endothelial glycocalyx degradation (as evidenced by reduced syndecan-1 and heparan sulfate levels) and suppresses systemic inflammation in patients undergoing gastrointestinal tumor resection. These mechanistic benefits were associated with improved microcirculatory perfusion, reduced postoperative complications, and enhanced recovery, including shorter hospital stay. The study identifies syndecan-1 as a potential biomarker for perioperative risk stratification and supports the integration of DEX as an endothelial-protective adjunct within Enhanced Recovery after Surgery protocols for oncologic surgery. |
| Publish Date |
2025-12-25 08:27 |
| Citation |
Zeng R, Tang CL, Zhao Y, Wang RX, Fang Y, Hu XW. Dexmedetomidine enhances recovery after gastrointestinal cancer surgery by protecting the endothelial glycocalyx: A randomized, double-blind, placebo-controlled study. World J Gastrointest Surg 2025; 17(12): 114628 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i12/114628.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i12.114628 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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