Publication Name	World Journal of Gastroenterology
Manuscript ID	11466
Country	Germany

Received	2014-05-22 20:39
Peer-Review Started	2014-05-23 14:01
To Make the First Decision	2014-06-18 17:16
Return for Revision	2014-06-20 11:32
Revised	2014-06-26 14:38
Second Decision	2014-07-25 09:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-25 09:39
Articles in Press	2014-07-25 09:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-23 00:10
Typeset the Manuscript	2014-12-24 19:11
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Establishment and characterization of cell lines from chromosomal instable colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Claudia Maletzki, Michael Gock, Martin Randow, Ernst Klar, Maja Huehns, Friedrich Prall and Michael Linnebacher
Funding Agency and Grant Number	Funding Agency Grant Number German Cancer Aid 108919
Corresponding Author	Michael Linnebacher, PhD, Section of Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, D-18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
Key Words	Patient-derived tumor model; Colorectal cancer; Individualized medicine; Molecular characterization; Drug response; Translational research
Core Tip	We ultra-low passage and well-characterized tumor models are considered the basis for modern preclinical research, but are still rare for colorectal carcinoma (CRC). Herein describe two novel ultra-low passage patient-derived CRC cell lines, HROC18 and HROC32, which were established both direct from patient material and after xenografting. We characterized these models according to phenotype, molecular, morphological, and growth characteristics, as well as by drug response profiles. These cell lines expand our comprehensive collection of tumor models, which in summary provide a useful instrument for basic and translational research. The models are available on request.
Publish Date	2015-01-07 11:07
Citation	Maletzki C, Gock M, Randow M, Klar E, Huehns M, Prall F, Linnebacher M. Establishment and characterization of cell lines from chromosomal instable colorectal cancer. World J Gastroenterol 2015; 21(1): 164-176
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/164.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.164

Full Article (PDF)	WJG-21-164.pdf
Full Article (Word)	WJG-21-164.doc
Manuscript File	11466-Review.doc
Answering Reviewers	11466-Answering reviewers.pdf
Copyright License Agreement	11466-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140522182102.tif
Peer-review Report	11466-Peer reviews.pdf
Scientific Misconduct Check	11466-CrossCheck.jpg
Scientific Editor Work List	11466-Scientific editor work list.pdf