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Articles Published Processes
1/21/2026 9:49:38 AM | Browse: 2 | Download: 1
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Received |
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2025-09-25 02:57 |
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Peer-Review Started |
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2025-09-25 02:57 |
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First Decision by Editorial Office Director |
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2025-10-29 09:30 |
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Return for Revision |
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2025-10-31 13:53 |
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Revised |
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2025-11-15 16:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-24 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-24 09:41 |
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Articles in Press |
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2025-12-24 09:41 |
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Edit the Manuscript by Language Editor |
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2025-12-30 23:30 |
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Typeset the Manuscript |
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2026-01-14 08:31 |
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Publish the Manuscript Online |
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2026-01-21 09:49 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Graft bile analysis for predicting post-transplant outcomes: A literature review and a protocol for a novel biomarker
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marco Maria Pascale, Jacopo Gervasoni, Giuseppe Bianco, Silvia Persichilli, Lorenzo Ferri, Aniello Primiano, Salvatore Agnes and Andrea Urbani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Maria Pascale, MD, General Surgery and Organ Transplant Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 8 Largo A Gemelli, Rome 00168, Lazio, Italy. marcomaria.pascale@policlinicogemelli.it |
| Key Words |
Bile; Biomarkers; Early allograft dysfunction; Tacrolimus; Protocol |
| Core Tip |
Early detection of graft dysfunction and rejection after liver transplantation remains challenging. This minireview highlights bile as an organ-specific biofluid directly reflecting hepatocellular and cholangiocyte function. We summarize the biochemical, metabolic, and molecular components of bile as predictive markers of graft viability during machine perfusion and in the perioperative period. Building on these insights, we present a prospective protocol assessing biliary tacrolimus concentration and introducing the blood-bile ratio of tacrolimus as a novel index for early, non-invasive detection of rejection. Integrating bile biomarkers into transplant workflows may enable real-time, graft-specific monitoring and improve post-transplant outcomes. |
| Publish Date |
2026-01-21 09:49 |
| Citation |
Pascale MM, Gervasoni J, Bianco G, Persichilli S, Ferri L, Primiano A, Agnes S, Urbani A. Graft bile analysis for predicting post-transplant outcomes: A literature review and a protocol for a novel biomarker. World J Gastrointest Surg 2026; 18(1): 114662 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i1/114662.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i1.114662 |
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