| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Chu Chen, Meng-Tzu Weng, Feng-Pai Tsai, Zhi-Che Chen, Hsin-Yun Wu, Chien-Chih Tung, Chun-Ying Wang and Shu-Chen Wei |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Council of Taiwan |
MOST 111-2314-B-002-188-MY3 |
| Liver Disease Prevention and Treatment Research Foundation |
|
|
| Corresponding Author |
Shu-Chen Wei, MD, PhD, Professor, Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chungshan South Road, Taipei 100, Taiwan. shuchenwei@ntu.edu.tw |
| Key Words |
Leucine-rich α-2-glycoprotein; Ulcerative colitis; Crohn’s disease; Inflammatory bowel disease; Biomarkers |
| Core Tip |
Endoscopy and fecal calprotectin (FC) are standard tools for examining disease activity in inflammatory bowel disease (IBD) but both have limitations. We evaluated serum leucine-rich α-2-glycoprotein (LRG) as a noninvasive biomarker in a Taiwanese IBD cohort. LRG correlated with FC, C-reactive protein (CRP), hemoglobin, and albumin. In ulcerative colitis, LRG predicted endoscopic activity, particularly in patients with normal CRP levels. Combining CRP, hemoglobin, and LRG significantly improved the endoscopic activity prediction to nearly that of FC. Our findings support the clinical utility of LRG as a complementary biomarker for disease monitoring in IBD, particularly in ulcerative colitis with low CRP. |
| Publish Date |
2026-01-16 11:31 |
| Citation |
Chen YC, Weng MT, Tsai FP, Chen ZC, Wu HY, Tung CC, Wang CY, Wei SC. Role of leucine-rich α-2-glycoprotein in Taiwanese patients with inflammatory bowel disease as a predictive biomarker for endoscopic activity. World J Gastroenterol 2026; 32(3): 114677 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i3/114677.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i3.114677 |
