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Articles Published Processes
4/14/2026 8:58:01 AM | Browse: 2 | Download: 4
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Received |
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2025-09-26 04:23 |
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Peer-Review Started |
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2025-09-29 08:09 |
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First Decision by Editorial Office Director |
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2025-10-21 06:29 |
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Return for Revision |
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2025-10-21 06:29 |
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Revised |
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2025-11-01 12:42 |
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Publication Fee Transferred |
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2025-11-03 08:59 |
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Second Decision by Editor |
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2025-12-03 09:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-05 07:02 |
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Articles in Press |
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2026-02-05 07:02 |
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Edit the Manuscript by Language Editor |
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2026-02-09 02:18 |
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Typeset the Manuscript |
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2026-04-02 00:28 |
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Publish the Manuscript Online |
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2026-04-14 08:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Hyperoside attenuates diabetic nephropathy by activating the Nrf2/SLC7A11/GPX4 axis to restrain ferroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao Liu, Yan Li, Yuan Zhang, Ming Gao and Shi-Feng Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shi-Feng Yang, MD, Department of Nephrology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. jeffysy@126.com |
| Key Words |
Hyperoside; Diabetic nephropathy; Ferroptosis; Nrf2; SLC7A11; GPX4; Oxidative stress |
| Core Tip |
This study, for the first time, demonstrates that hyperoside, a natural flavonoid, protects against diabetic nephropathy by suppressing ferroptosis via activation of the Nrf2/SLC7A11/GPX4 antioxidant axis. In high-glucose-challenged HK-2 cells, hyperoside restored glutathione, reduced lipid reactive oxygen species and Fe2+ accumulation, and improved cell viability, effects comparable to ferrostatin-1. In streptozotocin-induced diabetic nephropathy rats, hyperoside ameliorated renal dysfunction and histologic injury while upregulating Nrf2/SLC7A11/GPX4. These findings provide mechanistic and experimental support for hyperoside as a potential therapeutic candidate for diabetic nephropathy. |
| Publish Date |
2026-04-14 08:58 |
| Citation |
Liu C, Li Y, Zhang Y, Gao M, Yang SF. Hyperoside attenuates diabetic nephropathy by activating the Nrf2/SLC7A11/GPX4 axis to restrain ferroptosis. World J Diabetes 2026; 17(4): 114679 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i4/114679.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i4.114679 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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