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Articles Published Processes
1/22/2026 7:08:04 AM | Browse: 0 | Download: 0
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Received |
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2025-09-26 10:45 |
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Peer-Review Started |
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2025-09-26 10:45 |
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First Decision by Editorial Office Director |
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2025-11-04 09:34 |
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Return for Revision |
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2025-11-04 09:34 |
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Revised |
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2025-11-18 02:03 |
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Publication Fee Transferred |
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2025-11-22 22:31 |
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Second Decision by Editor |
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2026-01-08 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-08 08:21 |
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Articles in Press |
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2026-01-08 08:21 |
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Edit the Manuscript by Language Editor |
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2026-01-11 13:55 |
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Typeset the Manuscript |
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2026-01-19 01:00 |
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Publish the Manuscript Online |
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2026-01-22 07:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Early intervention in anxiety disorder with clinical high-risk factors for bipolar disorder: A randomized controlled trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong Wang, Shi-Liang Wang, Chen-Jie Ge, Li-Lei Lei, Lei Zeng and Min-Cai Qian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Huzhou Science and Technology Programmer |
2020GZ42 |
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| Corresponding Author |
Min-Cai Qian, Chief Physician, MD, Department of Psychosomatic Medicine, Huzhou Third Municipal Hospital Affiliated Hospital of Wenzhou Medical University, No. 2088 East Campsis Road, Wuxing District, Huzhou 313000, Zhejiang Province, China. 1311956613@qq.com |
| Key Words |
Anxiety disorder; Clinical high-risk factor; Bipolar disorder; Early intervention; Lithium |
| Core Tip |
This randomized controlled trial investigated early intervention in 66 antidepressant-naive adults with anxiety disorders who also presented clinical high-risk factors for bipolar disorder. The combination of sertraline and lithium demonstrated a significantly faster reduction in anxiety symptoms within the first four weeks compared to sertraline monotherapy, with comparable safety profiles. These preliminary findings suggest that early adjunctive mood stabilization may accelerate response and potentially mitigate the risk of manic switch in this clinically complex and high-risk population, warranting further investigation in larger trials. |
| Publish Date |
2026-01-22 07:08 |
| Citation |
Wang H, Wang SL, Ge CJ, Lei LL, Zeng L, Qian MC. Early intervention in anxiety disorder with clinical high-risk factors for bipolar disorder: A randomized controlled trial. World J Clin Cases 2026; 14(3): 114691 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i3/114691.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i3.114691 |
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