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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 114708
Country United States
Received
2025-09-26 07:09
Peer-Review Started
2025-09-26 07:09
First Decision by Editorial Office Director
2025-10-31 08:27
Return for Revision
2025-10-31 08:27
Revised
2025-11-08 11:16
Publication Fee Transferred
Second Decision by Editor
2025-11-27 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-11-27 06:38
Articles in Press
2025-11-27 06:38
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-04 02:06
Publish the Manuscript Online
2026-01-12 10:07
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Editorial
Article Title Revisiting multi-region 16S sequencing in gastric cancer
Manuscript Source Invited Manuscript
All Author List Liu Luo, Gang Huang, Hua Yang and Hao Chi
ORCID
Author(s) ORCID Number
Hao Chi http://orcid.org/0000-0002-5210-0770
Funding Agency and Grant Number
Corresponding Author Hao Chi, MD, Department of Quantitative Health Sciences, John A., Burns School of Medicine, University of Hawaii at Manoa,, 651 Ilalo Street, Honolulu, HI 96813, United States. chihao7511@gmail.com
Key Words Gastric cancer; Microbiome; Multi-region 16S rRNA sequencing; Metagenomics; Biomarkers; Prognosis; Immune microenvironment; Precision oncology
Core Tip Multi-region 16S rRNA sequencing represents a promising advance in gastric cancer microbiome research, improving microbial detection and taxonomic resolution compared to traditional methods. However, its clinical utility hinges on rigorous validation, integration with metagenomics and host factors, and the inclusion of health economic analyses. Future studies should aim to transform this technology from descriptive microbial profiling into a decision-support tool for prognosis, perioperative risk management, and personalized therapeutic strategies, overcoming existing methodological and translational challenges.
Publish Date 2026-01-12 10:07
Citation

Luo L, Huang G, Yang H, Chi H. Revisiting multi-region 16S sequencing in gastric cancer. World J Gastrointest Oncol 2026; 18(1): 114708

URL https://www.wjgnet.com/1948-5204/full/v18/i1/114708.htm
DOI https://dx.doi.org/10.4251/wjgo.v18.i1.114708
Full Article (PDF) WJGO-18-114708-with-cover.pdf
Manuscript File 114708_Auto_Edited_075324.docx
Answering Reviewers 114708-answering-reviewers.pdf
Audio Core Tip 114708-audio.mp3
Conflict-of-Interest Disclosure Form 114708-conflict-of-interest-statement.pdf
Copyright License Agreement 114708-copyright-assignment.pdf
Peer-review Report 114708-peer-reviews.pdf
Scientific Misconduct Check 114708-scientific-misconduct-check.png
Scientific Editor Work List 114708-scientific-editor-work-list.pdf
CrossCheck Report 114708-crosscheck-report.pdf