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Articles Published Processes
5/6/2026 8:34:22 AM | Browse: 3 | Download: 16
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Received |
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2025-11-18 09:34 |
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Peer-Review Started |
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2025-11-18 09:34 |
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First Decision by Editorial Office Director |
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2025-12-05 07:13 |
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Return for Revision |
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2025-12-05 07:13 |
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Revised |
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2025-12-18 12:50 |
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Publication Fee Transferred |
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2025-12-24 02:55 |
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Second Decision by Editor |
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2026-01-27 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-27 08:00 |
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Articles in Press |
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2026-01-27 08:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-23 02:15 |
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Publish the Manuscript Online |
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2026-05-06 08:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
LGALS1 drives chemoresistance in esophageal squamous cell carcinoma by modulating epithelial-mesenchymal transition and tumor immunity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-Hang Yan, Chen-Di Xu, Zhen-Guo Li, Yu-Zhen Zheng, Wing-Shing Wong, Da-Chuan Liang, Jie Yang, Wu-Guang Chang and Jun-Ye Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82173293 |
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| Corresponding Author |
Jun-Ye Wang, MD, Professor, Guangdong Esophageal Cancer Institute, Sun Yat-Sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. wangjy@sysucc.org.cn |
| Key Words |
Neoadjuvant chemoradiotherapy; Esophageal squamous cell carcinoma; Single-cell RNA sequencing; LGALS1; Cisplatin resistance |
| Core Tip |
In this investigation, we comprehensively characterized the dynamic changes in the immune microenvironment during treatment by analyzing single-cell RNA sequencing data of esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemoradiotherapy. LGALS1 was found to be a gene associated with neoadjuvant chemoradiotherapy resistance in ESCC. Subsequent experimental validation demonstrated LGALS1’s contribution to cisplatin resistance in ESCC through both in vitro and in vivo investigations. These studies illustrate ESCC cisplatin drug treatment failure mechanisms, emphasized the LGALS1 can serve as a promising therapeutic target. It also reveals a potential strategy to overcome the development of cisplatin resistance in ESCC, laying a foundation for the development of more effective individualized treatment regimens, and potentially leading to better outcomes for patients with advanced esophageal cancer. |
| Publish Date |
2026-05-06 08:34 |
| Citation |
Yan QH, Xu CD, Li ZG, Zheng YZ, Wong WS, Liang DC, Yang J, Chang WG, Wang JY. LGALS1 drives chemoresistance in esophageal squamous cell carcinoma by modulating epithelial-mesenchymal transition and tumor immunity. World J Gastroenterol 2026; 32(18): 114713 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i18/114713.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i18.114713 |
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