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2/28/2026 8:32:48 AM | Browse: 0 | Download: 0
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Received |
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2025-09-30 01:33 |
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Peer-Review Started |
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2025-09-30 01:34 |
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First Decision by Editorial Office Director |
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2025-11-06 08:43 |
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Return for Revision |
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2025-11-06 08:43 |
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Revised |
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2025-11-18 07:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-15 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-15 07:36 |
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Articles in Press |
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2025-12-15 07:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-13 03:59 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neuroimaging |
| Manuscript Type |
Observational Study |
| Article Title |
Significance of arterial spin labeling in relation to sertraline treatment response in adolescents with major depressive disorder
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao Liu, Chuan Liu, Yun-Zhen Pu, Dan Liu, Hong-Sheng Liu, Dan-Feng Xiang, Xiao-Yue Zhang, Xing-Yu Wang, Qian-Xi Yang, Rui Jin and Ren-Qiang Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The “Medicine + X” Program of Chongqing Translational Medicine Center |
No. Y+X202409 |
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| Corresponding Author |
Ren-Qiang Yu, Assistant Professor, PhD, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. yurenqiang@hospital.cqmu.edu.cn |
| Key Words |
Adolescent depression; Functional magnetic resonance imaging; Major depressive disorder; Cerebral blood flow; Arterial spin labeling |
| Core Tip |
Adolescent major depressive disorder is a global concern with limited treatment efficacy. This study used arterial spin labeling magnetic resonance imaging to evaluate cerebral blood flow changes during sertraline treatment and to examine whether baseline perfusion was associated with subsequent response. Thirty-three adolescents with adolescent major depressive disorder were assessed before and after eight weeks of treatment. A significant reduction in depressive symptoms was observed over eight weeks, and responders showed higher baseline cerebral blood flow in the right insula. These exploratory findings suggest that insular perfusion may index treatment-relevant states, but do not establish causality or predictive utility; confirmation in randomized, placebo or psychotherapy-controlled trials is required before informing clinical decision-making. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Liu X, Liu C, Pu YZ, Liu D, Liu HS, Xiang DF, Zhang XY, Wang XY, Yang QX, Jin R, Yu RQ. Significance of arterial spin labeling in relation to sertraline treatment response in adolescents with major depressive disorder. World J Psychiatry 2026; 16(3): 114719 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/114719.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.114719 |
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