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Articles Published Processes
1/30/2026 6:45:50 AM | Browse: 2 | Download: 0
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Received |
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2025-09-28 10:33 |
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Peer-Review Started |
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2025-09-28 10:33 |
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First Decision by Editorial Office Director |
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2025-10-21 09:34 |
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Return for Revision |
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2025-10-24 05:42 |
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Revised |
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2025-11-06 16:11 |
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Publication Fee Transferred |
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2025-11-10 04:28 |
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Second Decision by Editor |
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2025-12-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-09 06:48 |
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Articles in Press |
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2025-12-09 06:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-19 00:29 |
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Publish the Manuscript Online |
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2026-01-30 06:45 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Kun Ma, Shan-Lan Zhu, Xue-Yan Li, Yi Yuan, Qing-Yang Huang, Hao Wang, Guo-Ming Shen and Xi-Yang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82405244 |
| National Natural Science Foundation of China |
No. 82474224 |
| Research Project of Xin’an Medical and Chinese Medicine Modernization Research Institute |
No. 2023CXMMTCM016 |
| Excellent Youth Project of Anhui Universities |
No. 2022AH030065 |
| Open projects of Anhui Province Key Laboratory of Meridian Viscera Correlationship |
No. 2024AHMVC04 |
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| Corresponding Author |
Xi-Yang Wang, PhD, College of Integrated Chinese and Western Medicine (School of Life Science), Anhui University of Chinese Medicine, No. 350 Longzihu Road, Hefei 230012, Anhui Province, China. xiyangw1@163.com |
| Key Words |
Chronic stress; Depression; Central amygdala; GABAergic neurons; Electroacupuncture; Gastrointestinal motility; Gut-brain axis |
| Core Tip |
This study reveals the pivotal role of central amygdala (CeA) GABAergic neurons in mediating depressive-like behavior and gastrointestinal dysfunction in mice subjected to chronic unpredictable mild stress. Chemogenetic manipulation confirmed that CeA GABAergic hyperactivation drives these comorbidities, while inhibition alleviates them. Electroacupuncture reduced depressive symptoms and gastric impairment by modulating CeA GABAergic activity. These findings highlight electroacupuncture as a promising therapy for depression with gastrointestinal comorbidity, offering new mechanistic insights into brain-gut interactions. |
| Publish Date |
2026-01-30 06:45 |
| Citation |
Ma HK, Zhu SL, Li XY, Yuan Y, Huang QY, Wang H, Shen GM, Wang XY. Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala. World J Psychiatry 2026; 16(2): 114736 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i2/114736.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i2.114736 |
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