| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Tao Zhang, Hao Zhu, Xian-Cheng Chen, Tao Gao, Ming Chen, Zhang-Hua Zhu, Bei-Yuan Zhang and Wen-Kui Yu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Provincial Health Commission |
BJ24037 |
|
| Corresponding Author |
Wen-Kui Yu, Chief, MD, PhD, Professor, Department of Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. yudrnj2@163.com |
| Key Words |
Acute pancreatitis; Severity; Organ failure; Mortality; Cohort study |
| Core Tip |
The relationship between organ failure (OF) patterns and mortality in severe acute pancreatitis (AP) remains controversial. In this retrospective cohort of 151 patients with severe AP, we found that, after adjusting for initial multi-OF, the duration of OF, and infected pancreatic necrosis, the occurrence of new-onset OF - especially new-onset multi-OF - significantly increased both in-hospital and 90-day mortality rates. This novel perspective expands the theoretical framework linking OF patterns to adverse outcomes in AP and may prove pivotal for future pancreatitis grading systems and the design of related clinical trials. |
| Publish Date |
2026-02-06 08:53 |
| Citation |
Zhang XT, Zhu H, Chen XC, Gao T, Chen M, Zhu ZH, Zhang BY, Yu WK. New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis. World J Gastroenterol 2026; 32(7): 114773 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i7/114773.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i7.114773 |
