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Publication Name World Journal of Gastroenterology
Manuscript ID 114778
Country China
Received
2025-10-14 10:54
Peer-Review Started
2025-10-14 10:55
First Decision by Editorial Office Director
2025-11-14 09:21
Return for Revision
2025-11-14 09:21
Revised
2025-11-27 03:35
Publication Fee Transferred
2025-12-02 14:56
Second Decision by Editor
2026-02-02 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-02 09:51
Articles in Press
2026-02-02 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-02 06:16
Publish the Manuscript Online
2026-04-15 06:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Development and validation of a deep-learning-based diagnostic model for drug-induced liver injury using computed tomography images
Manuscript Source Unsolicited Manuscript
All Author List Shu-Yue Wang, Si-Qi Yin, Jie-Ying Yang, Ming-Yan Ji, Xiao-Qing Zeng, Sheng-Xiang Rao, Min-Zhi Lv, Jie Bao, Man-Ning Wang and Hong Gao
ORCID
Author(s) ORCID Number
Xiao-Qing Zeng http://orcid.org/0000-0003-3494-8636
Min-Zhi Lv http://orcid.org/0000-0002-7994-2257
Hong Gao http://orcid.org/0000-0002-2263-9214
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technique Commission of Shanghai Municipality 21Y11921800
Shanghai Municipal Health Commission 202540163
Corresponding Author Hong Gao, Chief Physician, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. gao.hong@zs-hospital.sh.cn
Key Words Deep learning; Diagnostic model; Hepatic sinusoidal obstruction syndrome; Drug induced liver injury; Computed tomography; Pyrrolizidine alkaloids
Core Tip This study developed the first deep learning model for diagnosing pyrrolizidine-alkaloid induced hepatic sinusoidal obstruction syndrome based on computed tomography images. The model integrates multiscale convolutional modules and an anatomy-based region of interest sampling strategy. Initial validation showed promising diagnostic performance, with potential to improve diagnostic consistency among clinicians and reduce image interpretation time, suggesting its possible utility as a clinical decision-support tool.
Publish Date 2026-04-15 06:47
Citation

Wang SY, Yin SQ, Yang JY, Ji MY, Zeng XQ, Rao SX, Lv MZ, Bao J, Wang MN, Gao H. Development and validation of a deep-learning-based diagnostic model for drug-induced liver injury using computed tomography images. World J Gastroenterol 2026; 32(15): 114778

URL https://www.wjgnet.com/1007-9327/full/v32/i15/114778.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i15.114778
Full Article (PDF) WJG-32-114778-with-cover.pdf
STROBE Statement 114778-STROBE-statement.pdf
Manuscript File 114778_Auto_Edited_072820.docx
Answering Reviewers 114778-answering-reviewers.pdf
Audio Core Tip 114778-audio.mp3
Biostatistics Review Certificate 114778-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 114778-conflict-of-interest-statement.pdf
Copyright License Agreement 114778-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 114778-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 114778-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 114778-non-native-speakers.pdf
Supplementary Material 114778-supplementary-material.pdf
Peer-review Report 114778-peer-reviews.pdf
Scientific Misconduct Check 114778-scientific-misconduct-check.png
Scientific Editor Work List 114778-scientific-editor-work-list.pdf
CrossCheck Report 114778-crosscheck-report.pdf