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12/19/2025 10:39:39 AM | Browse: 4 | Download: 3
Publication Name World Journal of Gastroenterology
Manuscript ID 114789
Country United Arab Emirates
Received
2025-09-28 01:04
Peer-Review Started
2025-09-28 01:04
First Decision by Editorial Office Director
2025-09-30 09:53
Return for Revision
2025-09-30 09:53
Revised
2025-10-05 17:51
Publication Fee Transferred
Second Decision by Editor
2025-10-31 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-31 06:41
Articles in Press
2025-10-31 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-09 11:25
Publish the Manuscript Online
2025-12-19 10:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Resistance reversal: Taiwan’s Helicobacter pylori trends defy global norms
Manuscript Source Invited Manuscript
All Author List Taly Issa, Pierre Zalloua and Iyad A Issa
ORCID
Author(s) ORCID Number
Iyad A Issa http://orcid.org/0000-0003-2050-2617
Funding Agency and Grant Number
Corresponding Author Iyad A Issa, MD, Department of Gastroenterology and Hepatology, Harley Street Medical Center, Marina Village, Villa No. A21, Abu Dhabi 41475, United Arab Emirates. iyadissa71@gmail.com
Key Words Antibiotics; Eradication; Helicobacter Pylori; Resistance; Proton pump inhibitors; Potassium-competitive acid blockers
Core Tip This multicenter Taiwanese study reveals a sharp rise in Helicobacter pylori tetracycline resistance once negligible, now clinically relevant threatening the efficacy of bismuth-based quadruple therapy. As dual resistance emerges and empiric regimens falter, potassium-competitive acid blockers (PCABs) offer a potent pharmacologic pivot. Integrating PCABs and resistance-guided strategies may be key to sustaining eradication success in the face of evolving antimicrobial threats.
Publish Date 2025-12-19 10:39
Citation

Issa T, Zalloua P, Issa IA. Resistance reversal: Taiwan’s Helicobacter pylori trends defy global norms. World J Gastroenterol 2025; 31(47): 114789

URL https://www.wjgnet.com/1007-9327/full/v31/i47/114789.htm
DOI https://dx.doi.org/10.3748/wjg.v31.i47.114789
Full Article (PDF) WJG-31-114789-with-cover.pdf
Manuscript File 114789_Auto_Edited_012530.docx
Answering Reviewers 114789-answering-reviewers.pdf
Audio Core Tip 114789-audio.mp3
Conflict-of-Interest Disclosure Form 114789-conflict-of-interest-statement.pdf
Copyright License Agreement 114789-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 114789-non-native-speakers.pdf
Peer-review Report 114789-peer-reviews.pdf
Scientific Misconduct Check 114789-scientific-misconduct-check.png
Scientific Editor Work List 114789-scientific-editor-work-list.pdf
CrossCheck Report 114789-crosscheck-report.pdf