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Articles Published Processes
2/26/2026 10:19:30 AM | Browse: 3 | Download: 1
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Received |
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2025-09-28 01:06 |
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Peer-Review Started |
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2025-09-28 01:06 |
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First Decision by Editorial Office Director |
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2025-10-23 07:35 |
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Return for Revision |
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2025-10-23 07:35 |
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Revised |
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2025-11-03 16:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-08 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-08 05:28 |
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Articles in Press |
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2025-12-08 05:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-05 01:13 |
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Publish the Manuscript Online |
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2026-02-26 10:19 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
From inflammation to precision medicine in colon cancer: Methodological considerations and future directions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arunkumar Krishnan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Arunkumar Krishnan, Assistant Professor, MD, Senior Scientist, Department of Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com |
| Key Words |
Colon cancer; Elderly; Precision medicine; Systemic immune-inflammation index; Lactoferrin; Prognostic biomarkers; Survival; Methodological critique |
| Core Tip |
A study by Zhu SS et al reported that the systemic immune-inflammation index and serum lactoferrin levels predict survival in elderly patients with colon cancer. While promising, the study was limited by a small, single-center cohort, a short follow-up period, and an incomplete adjustment for confounders. Predictive accuracy was only moderate, yet conclusions were overstated. To ensure clinical utility, future research should validate systemic immune-inflammation index and lactoferrin in larger, multicenter studies with longer follow-up, benchmark them against established prognostic indices, and incorporate molecular markers. Such efforts are crucial to establishing reliable, externally validated prognostic tools for the individualized management of older colon cancer patients. |
| Publish Date |
2026-02-26 10:19 |
| Citation |
Krishnan A. From inflammation to precision medicine in colon cancer: Methodological considerations and future directions. World J Gastrointest Surg 2026; 18(2): 114796 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i2/114796.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i2.114796 |
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