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Articles Published Processes
1/20/2026 2:54:05 AM | Browse: 1 | Download: 0
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Received |
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2025-09-29 01:31 |
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Peer-Review Started |
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2025-09-29 01:31 |
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First Decision by Editorial Office Director |
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2025-10-10 07:45 |
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Return for Revision |
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2025-10-10 07:45 |
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Revised |
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2025-10-29 21:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-01 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-02 08:53 |
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Articles in Press |
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2025-12-02 08:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-12 02:42 |
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Publish the Manuscript Online |
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2026-01-20 02:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Editorial |
| Article Title |
Harnessing CD146-positive mesenchymal stromal cells for precision therapy in acute respiratory distress syndrome
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Özlem Tomsuk |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific and Technological Research Council of Türkiye (TÜBİTAK) Under the International Postdoctoral Research Fellowship Program (2219) |
1059B192400980 |
| the National Postdoctoral Research Fellowship Program (2218) |
122C158 |
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| Corresponding Author |
Özlem Tomsuk, PhD, Senior Postdoctoral Fellow, Senior Scientist, Institut de Recherche en Cancérologie de Montpellier (IRCM), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Cancer de Montpellier (ICM), University of Montpellier, 124 Avenue des Apothicaires, Montpellier 34090, France. ozlem.tomsuk@inserm.fr |
| Key Words |
Acute respiratory distress syndrome; Mesenchymal stromal cells; CD146; Nuclear factor kappa B/cyclooxygenase-2 signaling pathway; Extracellular vesicles; Endothelial barrier repair; Precision medicine |
| Core Tip |
Acute respiratory distress syndrome remains a major significant clinical challenge for translational researchers because of its high mortality and paucity of effective therapies. Mesenchymal stromal cells (MSCs) present a promising approach for immunomodulation and barrier repair. However, heterogeneity within cell populations result in variable clinical efficacy. This editorial endorses the study by Zhang et al, which highlights greater therapeutic efficacy of the CD146+ MSC subpopulation through nuclear factor kappa B-mediated paracrine regulation. Furthermore, the authors highlight future directions including phenotype-focused manufacturing, multi-marker integration, and cell-free therapies based on extracellular vesicles or secretomes illustrating the potential of MSC-based interventions for precision medicine. |
| Publish Date |
2026-01-20 02:54 |
| Citation |
Tomsuk Ö. Harnessing CD146-positive mesenchymal stromal cells for precision therapy in acute respiratory distress syndrome. World J Stem Cells 2026; 18(1): 114825 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i1/114825.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i1.114825 |
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