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Articles Published Processes
4/21/2026 8:57:46 AM | Browse: 5 | Download: 11
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Received |
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2025-10-09 03:29 |
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Peer-Review Started |
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2025-10-09 03:29 |
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First Decision by Editorial Office Director |
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2025-11-24 12:45 |
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Return for Revision |
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2025-11-25 07:42 |
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Revised |
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2025-12-08 18:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-08 10:30 |
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Articles in Press |
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2026-01-08 10:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-09 01:05 |
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Publish the Manuscript Online |
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2026-04-21 08:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Serum alpha-fetoprotein dynamics in liver failure - prognostic implications and clinical insights
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xing-Xue Niu and Xiao-Jun Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Natural Science Foundation of Gansu Province |
25JRRA304 |
| The Intramural Research Fund of Gansu Provincial Hospital |
22GSSYA-3 |
| Doctoral Research Fund of the Key Laboratory of Diagnosis and Treatment of Gastrointestinal Tumors, National Health Commission of China |
NHCDP2022001 |
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| Corresponding Author |
Xiao-Jun Yang, MD, PhD, Professor, Department of General Surgery, Gansu Provincial Hospital, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com |
| Key Words |
Liver failure; Alpha-fetoprotein; Prognostic prediction; Acute-on-chronic liver failure; Hepatic regeneration; Wnt/β-catenin; STAT3; Immune response |
| Core Tip |
Guo et al highlighted that serum alpha-fetoprotein (AFP) kinetics may serve as an important prognostic indicator for patients with liver failure and help stratify risk in those receiving artificial liver support therapy. Despite limitations such as a small sample size and a lack of mechanistic validation, dynamic changes in AFP remain a promising complement to traditional prognostic scores. Future research should prioritize multicenter prospective validation and integrate AFP kinetics with multidimensional biomarkers and existing prognostic models, while also exploring regeneration-related signaling such as Wnt/β-catenin, STAT3, and immune pathways. |
| Publish Date |
2026-04-21 08:57 |
| Citation |
Niu XX, Yang XJ. Letter to the Editor: Serum alpha-fetoprotein dynamics in liver failure - prognostic implications and clinical insights. World J Hepatol 2026; 18(4): 114861 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i4/114861.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i4.114861 |
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