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Articles Published Processes
1/5/2026 3:46:20 AM | Browse: 106 | Download: 389
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Received |
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2025-10-09 03:23 |
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Peer-Review Started |
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2025-10-09 03:23 |
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First Decision by Editorial Office Director |
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2025-10-21 09:36 |
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Return for Revision |
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2025-10-21 09:36 |
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Revised |
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2025-11-02 08:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-13 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 08:43 |
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Articles in Press |
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2025-11-13 08:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-25 11:35 |
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Publish the Manuscript Online |
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2026-01-05 03:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sheng Xu and Guang-Rong Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Wenzhou Science and Technology Bureau |
No. Y20240207 |
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| Corresponding Author |
Guang-Rong Lu, MD, Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No. 1111 Wenzhou Avenue, Wenzhou 325000, Zhejiang Province, China. 210257@wzhealth.com |
| Key Words |
Cholelithiasis; Gallstone formation; Lysine succinylation; Inflammation; Adenosine monophosphate-activated protein kinase; Post-translational modification; Gallbladder |
| Core Tip |
The mechanisms of cholelithiasis are incompletely understood. The study by Wang et al is the first to demonstrate that lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase (AMPK) inhibits gallstone formation by activating the AMPK/silent information regulator 1 pathway and suppressing inflammation and pyroptosis in gallbladder mucosal epithelial cells. This finding provides a novel therapeutic target, filling a gap in succinylation research in cholelithiasis. After obtaining meaningful conclusions from basic research, more work is needed, specifically horizontal and vertical research expansions and verification using real-world patient specimens, to bridge the gap from basic research to clinical practice. |
| Publish Date |
2026-01-05 03:46 |
| Citation |
Xu S, Lu GR. Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy. World J Gastroenterol 2026; 32(1): 114865 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i1/114865.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i1.114865 |
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