| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Optimizing branch-duct intraductal papillary mucinous neoplasms surveillance: Data-driven dimensional grouping for risk stratification and cost-effectiveness
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Stefano Kayali, Simone Dibitetto, Alberto Busatto, Federica Gaiani, Andrea Pasta, Francesco Calabrese, Stefano Fantasia, Simone Caprioli, Andrea P Luzzi, Claudio G De Angelis, Edoardo V Savarino, Luigi Laghi, Edoardo G Giannini and Elisa Marabotto |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project ROTI 2022 ALTRIMIN POS “Chemogenomica Funzionale Per Il Futuro Delle Terapie Personalizzate Nelle Neoplasie Maligne” (codice T3-AN-05) |
No. CUP D93C22000610001 |
|
| Corresponding Author |
Stefano Kayali, MD, Research Fellow, Department of Medicine and Surgery, University of Parma, Viale Gramsci, 14, Parma 43121, Emilia-Romagna, Italy. stefano.kayali@unipr.it |
| Key Words |
Pancreatic cyst neoplasms; Intraductal papillary mucinous neoplasm; Risk stratification; Surveillance strategy; Cost-effectiveness; Pancreatic cancer; Evidence-based medicine; Health care costs |
| Core Tip |
Malignant degeneration of branch-duct intraductal papillary mucinous neoplasms is rare. Surveillance strategies can be optimized for both safety and cost-effectiveness. This study identifies data-driven cyst size thresholds of 1.5 cm and 3.0 cm and finds that the presence of at least two worrisome features, not just one, is an independent predictor of malignancy. A new surveillance protocol based on these findings maintains diagnostic accuracy while reducing 3-year costs by up to 21.4% compared to current international guidelines, particularly by safely extending follow-up intervals for the majority of patients with small cysts. |
| Publish Date |
2026-05-20 08:22 |
| Citation |
Kayali S, Dibitetto S, Busatto A, Gaiani F, Pasta A, Calabrese F, Fantasia S, Caprioli S, Luzzi AP, De Angelis CG, Savarino EV, Laghi L, Giannini EG, Marabotto E. Optimizing branch-duct intraductal papillary mucinous neoplasms surveillance: Data-driven dimensional grouping for risk stratification and cost-effectiveness. World J Gastroenterol 2026; 32(20): 114867 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i20/114867.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i20.114867 |
