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2/6/2026 8:43:38 AM | Browse: 1 | Download: 12
Publication Name World Journal of Diabetes
Manuscript ID 114900
Country Italy
Received
2025-10-09 00:18
Peer-Review Started
2025-10-10 00:07
First Decision by Editorial Office Director
2025-11-24 12:10
Return for Revision
2025-11-24 12:10
Revised
2025-11-25 12:56
Publication Fee Transferred
Second Decision by Editor
2026-01-04 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-04 06:15
Articles in Press
2026-01-04 06:15
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-27 02:32
Publish the Manuscript Online
2026-02-06 08:43
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Ophthalmology
Manuscript Type Editorial
Article Title Corneal neuropathy: An overlooked biomarker for dry eye in type 2 diabetes
Manuscript Source Invited Manuscript
All Author List Marco Zeppieri, Matteo Capobianco, Federico Visalli, Marieme Khouyyi, Caterina Gagliano and Francesco Cappellani
ORCID
Author(s) ORCID Number
Marco Zeppieri http://orcid.org/0000-0003-0999-5545
Caterina Gagliano http://orcid.org/0000-0001-8424-0068
Funding Agency and Grant Number
Corresponding Author Marco Zeppieri, Consultant, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words Type 2 diabetes; Corneal neuropathy; Dry eye syndrome; Ocular surface disease biomarkers; Inflammatory biomarkers; Oxidative stress; Precision medicine
Core Tip Dry eye disease in type 2 diabetes is not merely a surface ocular issue; it signifies underlying neurovascular and metabolic impairment. Han et al’s paper presents data correlating corneal nerve modifications with the severity of dry eye disease in patients with type 2 diabetes. Together with expanding findings on inflammatory biomarkers, immunological cross-talk, and global research trends, this body of evidence highlights the necessity to include ocular surface assessment into diabetes therapy. Future advancements will depend on precision medicine approaches, biomarker-directed screening, and medicines aimed at neuroinflammation and oxidative stress to maintain eyesight and enhance quality of life.
Publish Date 2026-02-06 08:43
Citation

Zeppieri M, Capobianco M, Visalli F, Khouyyi M, Gagliano C, Cappellani F. Corneal neuropathy: An overlooked biomarker for dry eye in type 2 diabetes. World J Diabetes 2026; 17(2): 114900

URL https://www.wjgnet.com/1948-9358/full/v17/i2/114900.htm
DOI https://dx.doi.org/10.4239/wjd.v17.i2.114900
Full Article (PDF) WJD-17-114900-with-cover.pdf
Manuscript File 114900_Auto_Edited_090518.docx
Answering Reviewers 114900-answering-reviewers.pdf
Audio Core Tip 114900-audio.m4a
Conflict-of-Interest Disclosure Form 114900-conflict-of-interest-statement.pdf
Copyright License Agreement 114900-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 114900-non-native-speakers.pdf
Peer-review Report 114900-peer-reviews.pdf
Scientific Misconduct Check 114900-scientific-misconduct-check.png
Scientific Editor Work List 114900-scientific-editor-work-list.pdf
CrossCheck Report 114900-crosscheck-report.pdf