| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Marina M G L Oliveira, Carol S Lemos, Mariangela L S Brazão, Alice L A Rodrigues, Evelin da C do Nascimento, Emylli M P Cardoso, Maria F F Arantes and Fabrício F de Melo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CNPq Research Productivity Fellow |
309110/2025-4 |
|
| Corresponding Author |
Fabrício F de Melo, Assistant Professor, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, No. 58 Rua Hormindo Barros, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com |
| Key Words |
Melanoma; Tumor microenvironment; Immunotherapy; Immune resistance; Immune checkpoints; Predictive biomarkers |
| Core Tip |
Melanoma represents a model disease for immuno-oncology, highlighting both the efficacy and limitations of immune-based therapies. Its highly immunogenic nature, coupled with the complexity of the tumor microenvironment, drives variable treatment responses and resistance to immune checkpoint blockade and targeted therapies. By integrating insights into tumor-immune interactions, resistance pathways, and predictive biomarkers, novel therapeutic strategies, particularly rational combinations of immunotherapy, targeted agents, and next-generation immunomodulators, are paving the way toward more durable and personalized clinical outcomes. |
| Publish Date |
2026-01-20 09:06 |
| Citation |
Oliveira MMGL, Lemos CS, Brazão MLS, Rodrigues ALA, do Nascimento EDC, Cardoso EMP, Arantes MFF, de Melo FF. Immune landscape of melanoma: Tumor microenvironment, resistance mechanisms, and predictive biomarkers. World J Clin Oncol 2026; 17(1): 114913 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i1/114913.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i1.114913 |
