Publication Name	World Journal of Gastroenterology
Manuscript ID	11492
Country	Italy

Received	2014-05-24 10:09
Peer-Review Started	2014-05-26 14:05
To Make the First Decision	2014-06-10 13:23
Return for Revision	2014-06-18 13:28
Revised	2014-06-22 22:48
Second Decision	2014-07-16 13:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-16 13:14
Articles in Press	2014-07-16 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-25 16:19
Publish the Manuscript Online	2014-12-10 15:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Lucia Pacifico, Enea Bonci, Lidia Marandola, Sara Romaggioli, Stefano Bascetta and Claudio Chiesa
Funding Agency and Grant Number
Corresponding Author	Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy. claudio.chiesa@ift.cnr.it
Key Words	Zonulin; Intestinal permeability; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Children
Core Tip	Alteration in gut microbiota followed by impairment of intestinal wall integrity may play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Zonulin is a mediator known to regulate intestinal permeability by modulating intracellular tight junctions. We showed that zonulin concentrations are increased in obese children with biopsy-proven NAFLD and correlate with the severity of steatosis, but not with the presence of nonalcoholic steatohepatitis (NASH), lobular inflammation or fibrosis score. These findings may well fit with the recent theory suggesting that simple steatosis and NASH are different and not necessarily inter-related diseases.
Publish Date	2014-12-10 15:52
Citation	Pacifico L, Bonci E, Marandola L, Romaggioli S, Bascetta S, Chiesa C. Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(45): 17107-17114
URL	http://www.wjgnet.com/1007-9327/full/v20/i45/17107.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i45.17107

Full Article (PDF)	WJG-20-17107.pdf
Full Article (Word)	WJG-20-17107.doc
Manuscript File	11492-Review.doc
Answering Reviewers	11492-Answering reviewers.pdf
Copyright License Agreement	11492-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11492-Language certificate.pdf
Peer-review Report	11492-Peer reviews.pdf
Scientific Misconduct Check	11492-CrossCheck.jpg
Scientific Editor Work List	11492-Scientific editor work list.pdf