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Articles Published Processes
1/12/2026 10:07:35 AM | Browse: 0 | Download: 0
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Received |
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2025-10-10 01:00 |
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Peer-Review Started |
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2025-10-10 01:00 |
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First Decision by Editorial Office Director |
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2025-10-23 08:35 |
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Return for Revision |
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2025-10-23 08:35 |
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Revised |
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2025-11-05 08:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-20 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-20 10:33 |
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Articles in Press |
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2025-11-20 10:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 02:12 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Solid dispersion of BIBR1532: A potent therapeutic for oesophageal squamous cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Juan Zhang, Nai-Xuan Deng, Huan-Qing Zhang, Jie-Zuan Cen, Zi-Xuan Zheng, Meng-Qin Guo and Zheng-Wei Huang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Continuation” Project of Excellent Doctors, Guangdong Basic and Applied Basic Research Foundation |
No. 2025A04J5082 |
| Guangdong Basic and Applied Basic Research Foundation |
No. 2024A1515011236 |
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| Corresponding Author |
Zheng-Wei Huang, Associate Professor, PhD, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511443, Guangdong Province, China. huangzhengw@jnu.edu.cn |
| Key Words |
BIBR1532; Solubility; Solid dispersion; Oesophageal squamous cancer; Hydroxypropyl methylcellulose; Druggability |
| Core Tip |
To overcome the poor aqueous solubility and low druggability of the anti-cancer agent BIBR1532, we proposed hydroxypropyl methylcellulose (HPMC)-based solid dispersion technology for solubilisation. This approach has lower costs and risks than lipid-based formulations for large-scale manufacturing. We selected an HPMC-based strategy because of its low hygroscopicity and high glass transition temperature. These properties ensure the release and absorption of the drug in the upper gastrointestinal tract, which is a key requirement for the treatment of esophageal squamous cell carcinoma. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Zhang XJ, Deng NX, Zhang HQ, Cen JZ, Zheng ZX, Guo MQ, Huang ZW. Solid dispersion of BIBR1532: A potent therapeutic for oesophageal squamous cancer. World J Gastrointest Oncol 2026; 18(1): 114924 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/114924.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.114924 |
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