| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Jiao Li, Xi Chen, Yong-Yin Luo, Jun Chang, Shu-Zhen Liu, Xiao-Qian Shan, Jing-Jing Song, Nan Hao, Xu-He Yan, Wei-Li Gao, Jian-Wei Liu and Lan Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074533 |
|
| Corresponding Author |
Lan Zhao, MD, PhD, Professor, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com |
| Key Words |
Neural stem cells; Hippocampal microenvironment; Acupuncture; MicroRNA-124; Notch signaling pathway; Wnt signaling pathway; Alzheimer’s disease |
| Core Tip |
Acupuncture improved hippocampal microenvironmental dysfunction in a mouse model of Alzheimer’s disease (AD), thereby enhancing the biological activity of transplanted neural stem cells (NSCs). Acupuncture reduced AD-related pathological biomarkers and upregulated microRNA-124, which concurrently targeted Notch homolog 1, hairy and enhancer of split 5, and glycogen synthase kinase 3β, modulating the Notch and Wnt signaling pathways. This dual pathway regulated cyclin D1-mediated NSCs proliferation and differentiation, and promoted neural circuit remodeling. Consequently, AD pathology was markedly suppressed. Our study identified microRNA-124/Notch-Wnt as a promising therapeutic target and suggests that sustained acupuncture is a viable strategy for mitigating irreversible neurofunctional deficits in AD. |
| Publish Date |
2026-03-25 08:45 |
| Citation |
Li YJ, Chen X, Luo YY, Chang J, Liu SZ, Shan XQ, Song JJ, Hao N, Yan XH, Gao WL, Liu JW, Zhao L. Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways. World J Stem Cells 2026; 18(3): 114929 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i3/114929.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i3.114929 |
