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2/9/2026 7:34:02 AM | Browse: 1 | Download: 7
Publication Name World Journal of Cardiology
Manuscript ID 114960
Country China
Received
2025-10-10 06:55
Peer-Review Started
2025-10-10 06:55
First Decision by Editorial Office Director
2025-10-22 06:51
Return for Revision
2025-10-22 06:51
Revised
2025-11-05 06:28
Publication Fee Transferred
Second Decision by Editor
2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-18 08:56
Articles in Press
2025-12-18 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-02-02 07:46
Publish the Manuscript Online
2026-02-09 07:34
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Minireviews
Article Title Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies
Manuscript Source Unsolicited Manuscript
All Author List Sze-Hua Tan, Jia-Lin Wu, Shu-Xiong Zhuo, Yi Zhang and Miao Wang
ORCID
Author(s) ORCID Number
Sze-Hua Tan http://orcid.org/0009-0002-5474-7233
Miao Wang http://orcid.org/0000-0002-0344-7575
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Pudong New Area Health System Excellent Young Medical Talent Training Program No. PWRq2025-39
Corresponding Author Miao Wang, Chief Physician, MD, PhD, Department of Internal Medicine of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Xuhui District, Shanghai 200032, China. wangmiao_126@126.com
Key Words Atherosclerosis; Cardiovascular disease; Inflammation; Lipid metabolism; Lipoprotein(a); Residual risk; Statins; Triglycerides
Core Tip Residual cardiovascular risk remains in patients receiving statin therapy despite well-controlled low-density lipoprotein cholesterol. Key contributors include non-high-density lipoprotein cholesterol, apolipoprotein B, lipoprotein(a), triglycerides, and persistent inflammation marked by high-sensitivity C-reactive protein and interleukin-6. Comprehensive strategies combining novel lipid-lowering therapies, anti-inflammatory treatments, lifestyle modification, and gene-silencing approaches are essential to effectively reduce residual risk and improve long-term cardiovascular outcomes.
Publish Date 2026-02-09 07:34
Citation

Tan SH, Wu JL, Zhuo SX, Zhang Y, Wang M. Residual risk in atherosclerotic cardiovascular disease after statin therapy: Clinical mechanisms and management strategies. World J Cardiol 2026; 18(2): 114960

URL https://www.wjgnet.com/1949-8462/full/v18/i2/114960.htm
DOI https://dx.doi.org/10.4330/wjc.v18.i2.114960
Full Article (PDF) WJC-18-114960-with-cover.pdf
Manuscript File 114960_Auto_Edited_114715.docx
Answering Reviewers 114960-answering-reviewers.pdf
Audio Core Tip 114960-audio.m4a
Conflict-of-Interest Disclosure Form 114960-conflict-of-interest-statement.pdf
Copyright License Agreement 114960-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 114960-non-native-speakers.pdf
Peer-review Report 114960-peer-reviews.pdf
Scientific Misconduct Check 114960-scientific-misconduct-check.png
Scientific Editor Work List 114960-scientific-editor-work-list.pdf
CrossCheck Report 114960-crosscheck-report.pdf