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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1218 | Download: 1786
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Received |
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2014-05-24 12:01 |
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Peer-Review Started |
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2014-05-24 12:03 |
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To Make the First Decision |
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2014-07-15 11:03 |
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Return for Revision |
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2014-08-22 16:22 |
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Revised |
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2014-12-03 20:09 |
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Second Decision |
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2014-12-19 08:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-12-22 16:55 |
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Articles in Press |
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2014-12-22 17:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-05 18:15 |
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Typeset the Manuscript |
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2015-01-28 12:46 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong Zhou, Peng Dong, Yu-Min Li, Fa-Cai Guo, An-Ping Zhang, Run-Ze Song, Ya-Min Zhang, Zhi-Yong Li, Dong Yuan and Chuan Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Gansu Provincial Natural Science Foundation |
1308RJZA188 |
| Fundamental Research Funds for the Central Universities |
lzujbky-2011-T03-16 |
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| Corresponding Author |
Yu-Min Li, PhD, Professor, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, 82 Cuiyingmen, Lanzhou 730030, Gansu Province, China. 13919951166@139.com |
| Key Words |
Csk-binding protein; Esophageal carcinoma; Cell growth; Invasion; Migration |
| Core Tip |
Csk-binding protein (CBP) is a ubiquitously expressed transmembrane protein and functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src. Here, we established a CBP overexpressing esophageal carcinoma cell line (TE-1) and found that the overexpression of CBP significantly decreased the proliferation, invasion, and migration of TE-1 cells, accompanied by decreased activation of Src. These results indicate that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. Targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Zhou D, Dong P, Li YM, Guo FC, Zhang AP, Song RZ, Zhang YM, Li ZY, Yuan D, Yang C. Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation. World J Gastroenterol 2015; 21(6): 1814-1820 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1814.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1814 |
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