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Articles Published Processes
1/28/2026 9:23:39 AM | Browse: 1 | Download: 0
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Received |
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2025-10-09 16:12 |
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Peer-Review Started |
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2025-10-09 16:12 |
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First Decision by Editorial Office Director |
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2025-11-06 09:30 |
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Return for Revision |
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2025-11-06 09:30 |
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Revised |
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2025-11-14 12:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-19 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-19 09:14 |
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Articles in Press |
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2025-12-19 09:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-20 00:28 |
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Publish the Manuscript Online |
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2026-01-28 09:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Fei Cheng |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Fei Cheng, Associate Chief Physician, MD, PhD, Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Raod, Hangzhou 310003, Zhejiang Province, China. xfcheng@zju.edu.cn |
| Key Words |
Colorectal cancer; Adjuvant therapy; Molecular subtyping; Consensus molecular subtypes; Circulating tumor DNA; Precision medicine |
| Core Tip |
Molecular profiling, including mismatch repair deficiency/microsatellite instability, circulating tumor DNA (ctDNA), and consensus molecular subtypes, refines risk stratification and guides personalized adjuvant therapy in colorectal cancer. Persistent gaps between guidelines and practice stem from technical variability, limited evidence for novel strategies (e.g., ctDNA-guided escalation), and health economic disparities. Bridging these requires integrated artificial intelligence-multiomics decision tools, dynamic ctDNA monitoring, and health policy reforms supporting equitable implementation. |
| Publish Date |
2026-01-28 09:23 |
| Citation |
Cheng XF. Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities. World J Gastroenterol 2026; 32(5): 115009 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i5/115009.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i5.115009 |
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