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Articles Published Processes
1/27/2026 10:12:30 AM | Browse: 0 | Download: 0
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Received |
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2025-10-09 02:30 |
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Peer-Review Started |
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2025-10-09 02:30 |
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First Decision by Editorial Office Director |
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2025-10-21 07:30 |
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Return for Revision |
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2025-10-21 07:30 |
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Revised |
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2025-10-21 18:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-24 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-24 07:47 |
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Articles in Press |
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2025-11-24 07:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-13 03:40 |
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Publish the Manuscript Online |
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2026-01-27 10:12 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Whole-exome sequencing illuminates unexplained pediatric cholestatic liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Toshifumi Yodoshi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Toshifumi Yodoshi, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, United States. toshifumi.yodoshi@cchmc.org |
| Key Words |
Pediatric cholestasis; Genetic diagnosis; Whole exome sequencing; Precision medicine; Alagille syndrome; Wilson disease; Inherited metabolic liver disease |
| Core Tip |
The advent of whole-exome sequencing (WES) has transformed diagnosis of unexplained pediatric liver disease. In infants with cholestasis and children with cryptogenic hepatitis, comprehensive genomic testing markedly increases diagnostic yield, often exceeding 50% in recent cohorts, enabling earlier identification and management. Incorporating WES early can spare patients invasive procedures, including diagnostic liver biopsy, and facilitate timely, targeted interventions. Yet, given phenotypic heterogeneity, WES must be integrated with careful clinical assessment, family history, and selective traditional diagnostics. Falling costs and faster turnaround make WES a practical cornerstone of precision hepatology, while validation and multi-omics remain essential to realize its full potential. |
| Publish Date |
2026-01-27 10:12 |
| Citation |
Yodoshi T. Whole-exome sequencing illuminates unexplained pediatric cholestatic liver disease. World J Hepatol 2026; 18(1): 115037 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i1/115037.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i1.115037 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
