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Articles Published Processes
5/26/2026 3:52:11 AM | Browse: 0 | Download: 0
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Received |
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2025-10-09 16:13 |
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Peer-Review Started |
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2025-10-09 16:13 |
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First Decision by Editorial Office Director |
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2025-11-14 06:45 |
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Return for Revision |
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2025-11-14 06:45 |
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Revised |
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2025-12-26 12:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-16 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-16 06:37 |
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Articles in Press |
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2026-03-16 06:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-14 08:15 |
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Publish the Manuscript Online |
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2026-05-26 03:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Navigating the therapeutic tightrope: Precision use of plasmapheresis and continuous renal replacement therapy in liver failure
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Manish Manrai, Aditya V Pachisia, Saurabh Dawra, Siddharth Shukla and Atul A Jha |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Manish Manrai, FRCPE, Professor, Department of Gastroenterology, Command Hospital, Lucknow Cantt, Lucknow 226002, Uttar Pradesh, India. manishmanrai75@gmail.com |
| Key Words |
Acute liver failure; Acute-on-chronic liver failure; Therapeutic plasma exchange; Continuous renal replacement therapy; Extracorporeal therapies; Multiorgan failure |
| Core Tip |
Therapeutic plasma exchange (TPE) and continuous renal replacement therapy (CRRT) are essential for managing acute liver failure (ALF) and acute-on-chronic liver failure. High-volume TPE excels in ALF for rapid clearance of protein-bound toxins, while standard-volume TPE is better suited for acute-on-chronic liver failure’s hemodynamically fragile patients. CRRT addresses renal failure and ammonia spikes, particularly in ALF’s encephalopathy. Sequential TPE-CRRT is safer and more feasible, while combined approaches are reserved for severe, rapidly deteriorating cases. Emerging biomarkers (e.g., interleukin-6, neutrophil gelatinase-associated lipocalin) hold promise for guiding therapy, but access disparities and non-standardized protocols necessitate global standardization and innovative solutions to enhance survival. This review synthesizes the optimal requirement of TPE and CRRT. |
| Publish Date |
2026-05-26 03:52 |
| Citation |
Manrai M, Pachisia AV, Dawra S, Shukla S, Jha AA. Navigating the therapeutic tightrope: Precision use of plasmapheresis and continuous renal replacement therapy in liver failure. World J Hepatol 2026; 18(5): 115047 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i5/115047.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i5.115047 |
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