| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Manjeet Kumar Goyal, Rishi Chowdhary, Chirag Vohra, Megh Patel, Shivam Kalra, Madhav Mehta, Rachel McNulty, Kartikay Goyal, Ashita Rukmini Vuthaluru and Omesh Goyal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Omesh Goyal, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com |
| Key Words |
Cirrhosis; Sarcopenia; Frailty; Liver transplant; Malnutrition; Hyperammonemia; Exercise therapy; Branched-chain amino acids |
| Core Tip |
Sarcopenia and frailty are underrecognized yet powerful predictors of outcomes in cirrhosis, influencing decompensation, hospitalizations, transplantation waitlist dropout, and post-transplant survival independent of the model for end-stage liver disease score. Simple bedside tools such as handgrip strength, chair stands, gait speed, and the Liver Frailty Index as well as imaging-based skeletal muscle measures enable early recognition. Incorporating routine assessment and structured prehabilitation, including adequate nutrition, resistance and aerobic exercise, and management of cirrhosis complications, can improve quality of life, reduce adverse outcomes, and optimize transplant candidacy. |
| Publish Date |
2026-01-27 10:12 |
| Citation |
Goyal MK, Chowdhary R, Vohra C, Patel M, Kalra S, Mehta M, McNulty R, Goyal K, Vuthaluru AR, Goyal O. Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy. World J Hepatol 2026; 18(1): 115048 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i1/115048.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i1.115048 |
