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Articles Published Processes
7/24/2026 10:16:19 AM | Browse: 2 | Download: 0
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Received |
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2025-10-09 15:46 |
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Peer-Review Started |
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2025-10-09 15:46 |
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First Decision by Editorial Office Director |
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2025-11-04 07:56 |
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Return for Revision |
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2025-11-04 07:56 |
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Revised |
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2025-11-22 17:57 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-26 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-26 09:41 |
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Articles in Press |
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2026-01-26 09:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-11 04:34 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Sclerostin knockdown in human umbilical cord mesenchymal stem cells confers superior therapeutic efficacy against steroid-induced osteonecrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei Zhang and Wen-Hui Chu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wen-Hui Chu, Associate Professor, PhD, School of Life Science, Taizhou University, No. 1139 Shifu Avenue, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. jake-chu@hotmail.com |
| Key Words |
Sclerostin; Human umbilical cord mesenchymal stem cells; Steroid-induced avascular necrosis of the femoral head; Bone metabolism; Wnt/β-catenin signaling; RNA interference; Gene therapy |
| Core Tip |
This study demonstrates that sclerostin (SOST) gene silencing in human umbilical cord mesenchymal stem cells enhances their therapeutic efficacy in a steroid-induced osteonecrosis model. Genetically modified SOST-silenced human umbilical cord mesenchymal stem cells significantly improved bone microarchitecture, promoted osteogenic differentiation, and inhibited adipogenic formation by activating the Wnt/β-catenin pathway. This targeted approach effectively restored the bone metabolic balance, positioning SOST-silenced human umbilical cord mesenchymal stem cells as a promising advanced regenerative strategy for the treatment of steroid-induced femoral head necrosis. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Zhang W, Chu WH. Letter to the Editor: Sclerostin knockdown in human umbilical cord mesenchymal stem cells confers superior therapeutic efficacy against steroid-induced osteonecrosis. World J Stem Cells 2026; 18(7): 115076
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/115076.htm |
| DOI |
https://doi.org/10.4252/wjsc.115076 |
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