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Articles Published Processes
3/23/2026 8:21:10 AM | Browse: 0 | Download: 0
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Received |
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2025-10-09 17:13 |
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Peer-Review Started |
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2025-10-09 17:13 |
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First Decision by Editorial Office Director |
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2025-11-05 07:49 |
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Return for Revision |
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2025-11-05 07:49 |
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Revised |
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2025-11-10 10:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-19 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-19 10:14 |
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Articles in Press |
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2026-01-19 10:14 |
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Edit the Manuscript by Language Editor |
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2026-01-26 00:57 |
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Typeset the Manuscript |
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2026-03-16 03:16 |
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Publish the Manuscript Online |
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2026-03-23 08:21 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Metabolic axis of autophagy: A key player in tumor maintenance and opportunities for therapeutic exploitation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Minal Garg |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Indian Council of Medical Research, Govt. of India |
No. 5/3/8/24/2020-ITR |
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| Corresponding Author |
Minal Garg, Full Professor, Department of Biochemistry and Director, Institute of Advanced Molecular Genetics and Infectious Diseases, University of Lucknow, University Road, Lucknow 226007, Uttar Pradesh, India. garg_minal@lkouniv.ac.in |
| Key Words |
Anti-cancer therapies; Autophagy activation and inhibition; Paradoxical role of autophagy; Metabolic rewiring; Therapy resistance |
| Core Tip |
Autophagy is an evolutionary conserved catabolic process that ensures cell adaptability under stress conditions and maintains cellular homeostasis. Dysregulation of autophagy supports tumor growth where its paradoxical role (protective and supportive) appears to depend on tumor stage, driver mutations, tissue type and metabolic sensitivity. Production of metabolic fuel sources and extracellular energy in an autophagy dependent manner contribute to autophagic switch. Pharmacological inhibition of autophagy or depletion of core autophagic genes have been significantly shown to impair metabolism and suppress tumor proliferation. Many recent studies argue that disruption of autophagy/core autophagic genes may potentiate the genomic instability under metabolic stress conditions and drive tumor development. Paradoxical change in the functions of autophagy-dependent metabolic crosstalk in tumor maintenance and disease aggressiveness emphasizes the therapeutic exploitation of supplemental approaches. |
| Publish Date |
2026-03-23 08:21 |
| Citation |
Garg M. Metabolic axis of autophagy: A key player in tumor maintenance and opportunities for therapeutic exploitation. World J Clin Oncol 2026; 17(3): 115094 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i3/115094.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i3.115094 |
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