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Articles Published Processes
3/30/2026 8:58:28 AM | Browse: 38 | Download: 163
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Received |
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2025-10-09 17:15 |
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Peer-Review Started |
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2025-10-09 17:16 |
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First Decision by Editorial Office Director |
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2025-11-04 05:51 |
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Return for Revision |
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2025-11-04 05:51 |
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Revised |
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2025-11-20 14:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-23 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-23 07:18 |
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Articles in Press |
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2025-12-23 07:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-16 09:47 |
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Publish the Manuscript Online |
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2026-03-30 08:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Attenuating neuropsychiatric disorders of early-life stress: The protective role of oxytocin
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yuan Zhang, Shu Wang and Ming-Yan Hei |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming-Yan Hei, MD, Professor, Neonatal Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No. 56 Nanlishi Road, Beijing 100045, China. heimingyan@bch.com.cn |
| Key Words |
Early-life stress; Oxytocin; Neuropsychiatric disorders; Neurodevelopment; Hypothalamic-pituitary-adrenal axis; Clinical trials; Precision medicine |
| Core Tip |
Early-life stress increases lifelong risk for neuropsychiatric disorders via lasting neural, endocrine, and epigenetic changes. Oxytocin, a key neuropeptide, shows promise in mitigating these effects by normalizing amygdala-prefrontal connectivity, reducing hypothalamic-pituitary-adrenal axis hyperactivity, promoting hippocampal neurogenesis, and reversing stress-associated epigenetic marks. However, its efficacy is context-dependent and influenced by factors like sex, timing, and administration route. Future oxytocin-based therapies should be integrated with psychosocial support and tailored through a precision medicine framework to effectively promote resilience in the affected individuals. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Zhang Y, Wang S, Hei MY. Attenuating neuropsychiatric disorders of early-life stress: The protective role of oxytocin. World J Psychiatry 2026; 16(4): 115109 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115109.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115109 |
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