| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
From steatosis to inflammation: Innate lymphocytes as hidden orchestrators in metabolic dysfunction-associated steatotic liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cesar A San Juan-Garcia, Rita I Escamilla, Lucia Cruz-Romero, Christian D Hernandez-Silva, David Fernandez-Quezada, Ulises De la Cruz-Mosso, Ana L Pereira-Suarez, Jesse Haramati, Inocencia G Ramirez-Lopez, Jose Macias-Barragan and Margarita Montoya-Buelna |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Centro Universitario de Ciencias de la Salud Universidad de Guadalajara |
No. PIN 2024-V |
| Universidad de Guadalajara |
No. PROSNI 2025 |
|
| Corresponding Author |
Margarita Montoya-Buelna, Principal Investigator, Professor, Researcher, Instituto de Investigación en Inmunología, Departamento de Fisiología, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico. margarita.montoya@academicos.udg.mx |
| Key Words |
Innate lymphocytes cells; Gamma delta T cells; Mucosal-associated invariant T cells; Natural killer cells; Natural killer T cell; Metabolic dysfunction-associated steatotic liver disease; Fibrosis |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease is now recognized as a leading cause of chronic liver disease worldwide. Beyond metabolic stress and hepatocellular injury, recent evidence highlights the critical involvement of innate and innate-like lymphocytes, such as gamma delta T cells, natural killer cells, natural killer T cells, innate lymphoid cells, and mucosal-associated invariant T cells in driving inflammation, hepatocyte injury, and hepatic stellate cell activation. Depending on the microenvironment, these cells may exert protective or pathogenic roles, shaping progression toward steatohepatitis and fibrosis. Understanding their effector functions offers opportunities for novel biomarkers and therapeutic strategies in metabolic dysfunction-associated steatotic liver disease. |
| Publish Date |
2026-03-26 09:22 |
| Citation |
San Juan-Garcia CA, Escamilla RI, Cruz-Romero L, Hernandez-Silva CD, Fernandez-Quezada D, Cruz-Mosso UDL, Pereira-Suarez AL, Haramati J, Ramirez-Lopez IG, Macias-Barragan J, Montoya-Buelna M. From steatosis to inflammation: Innate lymphocytes as hidden orchestrators in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2026; 18(3): 115111 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i3/115111.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i3.115111 |
