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Articles Published Processes
1/28/2026 9:23:39 AM | Browse: 1 | Download: 0
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Received |
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2025-10-09 16:03 |
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Peer-Review Started |
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2025-10-09 16:03 |
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First Decision by Editorial Office Director |
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2025-11-14 09:20 |
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Return for Revision |
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2025-11-14 09:20 |
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Revised |
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2025-11-24 14:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-16 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-16 09:16 |
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Articles in Press |
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2025-12-16 09:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-19 01:38 |
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Publish the Manuscript Online |
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2026-01-28 09:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Revisiting HLA-DQA1*05 in Asian inflammatory bowel disease cohorts: Ethnic variations in genetic susceptibility to immunogenicity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chao-Qun Hu, Xiao-Mei Song, Yong-Sheng Teng and Hong Guo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Science and Health Joint Medical Research Program of Chongqing Municipality |
2024ZDXM009 |
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| Corresponding Author |
Hong Guo, Professor, Department of Gastroenterology, Chongqing General Hospital, Chongqing University, No. 118 Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China. hguo_cgh2021@163.com |
| Key Words |
Inflammatory bowel disease; Anti-tumor necrosis factor therapy; Anti-drug antibodies; Human leukocyte antigen genotype; Ethnic variation |
| Core Tip |
This letter builds upon Weng et al’s study in Taiwan that incorporated comparative evidence from Asia and Europe toward the investigation of racial disparities in human leukocyte antigen (HLA)-related immunogenicity of anti-tumor necrosis factor therapy. Although Weng et al did not identify an association between HLA-DQA1*05 and the development of anti-drug antibody against infliximab and adalimumab, other larger-scale studies across Chinese and European cohorts demonstrated a significant correlation between HLA-DQA1*05 and anti-drug antibody formation, particularly with infliximab, highlighting the genetic diversity within Asia. The novel alleles reported by Weng et al warrant further validation. Until further comprehensive, large-scale racial cohort data becomes available, clinicians should prioritize therapeutic drug monitoring and individualized treatment approaches. Furthermore, HLA allele screening for inflammatory bowel disease treatment decisions requires support from larger, genetically diverse cohort studies. |
| Publish Date |
2026-01-28 09:23 |
| Citation |
Hu CQ, Song XM, Teng YS, Guo H. Revisiting HLA-DQA1*05 in Asian inflammatory bowel disease cohorts: Ethnic variations in genetic susceptibility to immunogenicity. World J Gastroenterol 2026; 32(5): 115120 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i5/115120.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i5.115120 |
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