| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Li Xu, Ting-Ting Luo, Qi Liu, Gu-Zhen Cui, Dao-Yan Wu, Xiao-Juan Wu, Ting-Xiu Yang, Jian-Chao Sun, Hui-Feng Jian, Shu-Wei Zhuo and Zheng-Hong Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation of China |
82260402 |
| Research Foundation of The Affiliated Hospital of Guizhou Medical University |
GYFYMF002 |
| Central-Guided Local Science and Technology Projects of Guizhou Province |
Qiankehe [2025] 024 |
| Guizhou Key Laboratory |
ZDSYS[2023]004 |
| Guizhou Provincial Key Laboratory for Digestive System Diseases |
ZSYS[2025]021 |
| Basic Research Program of Guizhou Science and Technology Plan |
ZK[2022]341 |
| National Science Foundation of Hainan |
82QN0993 |
| Research Foundation of The Affiliated Hospital of Guizhou Medical University |
GYFYMF001 |
| Basic Research Program of Guizhou Science and Technology Plan |
ZK[2022]368 |
|
| Corresponding Author |
Zheng-Hong Chen, PhD, Professor, Guizhou Key Laboratory of Microbio and Infectious Disease Prevention and Control, Guizhou Medical University, No. 6 Ankang Avenue, Gui’an New Area 561113, Guizhou Province, China. chenzhenghong@gmc.edu.cn |
| Key Words |
Helicobacter pylori; Candida; Internalization; Reservoir; Vertical transmission |
| Core Tip |
A comprehensive understanding of the familial pathway for Helicobacter pylori (H. pylori) transmission is essential for establishing effective infection prevention and control measures. However, the route through which this pathogen is transmitted remains unclear. Our preliminary findings had revealed that H. pylori can internalize within Candida cells, and that maternal vaginal colonization of Candida may serve as a potential route for transmission to neonates during childbirth. On the basis of animal experiments, we seek to confirm the transmission of H. pylori-positive Candida from maternal mice to their offspring during birth, potentially leading to H. pylori infection in the offspring. |
| Publish Date |
2026-02-06 08:53 |
| Citation |
Xu XL, Luo TT, Liu Q, Cui GZ, Wu DY, Wu XJ, Yang TX, Sun JC, Jian HF, Zhuo SW, Chen ZH. Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice. World J Gastroenterol 2026; 32(7): 115143 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i7/115143.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i7.115143 |
