| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Induction with anti-T-lymphocyte globulins and human immunoglobulins: A strategy for hyperimmunized liver transplant patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nada EL-Domiaty, Audrey Coilly, Mylene Sebagh, Jean-Luc Taupin, Wafaa Ibrahim, Sophie-Caroline Sacleux, Philippe Ichai, Lea Duhaut, Gabriella Pittau, Oriana Ciacio, Chady Salloum, Antonio Sa-Cunha, Daniel Azoulay, Cyrille Feray, Daniel Cherqui, Gamal Shiha, Didier Samuel and Faouzi Saliba |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Faouzi Saliba, PhD, Professor, Hepato-Biliary Centre, Villejuif-France, INSERM UMR 1193 & Université Paris Saclay, AP-HP Hôpital Paul Brousse, 12, Avenue Paul Vaillant Couturier, villejuif 94800, France. faouzi.saliba@aphp.fr |
| Key Words |
Antibody-mediated rejection; Acute T-cell mediated rejection; Hyperimmunized recipients; Crossmatch; Donor specific antibodies; Liver transplantation |
| Core Tip |
For hyperimmunized liver transplant recipients with high mean fluorescence intensity titer of pre-formed donor-specific antibodies and/or donor/recipient positive crossmatch, early induction with a short course of rabbit anti-T-lymphocyte globulins combined with high-dose intravenous immune-globulins can be a valuable strategy for mitigating early immunological risks (T-cell mediated rejection, acute antibody-mediated rejection severity and graft loss). If allograft dysfunction is suspected, closer serial donor-specific antibodies monitoring and early liver biopsy should be considered for timely diagnosis and management of antibody-mediated injury. |
| Publish Date |
2026-03-26 09:22 |
| Citation |
EL-Domiaty N, Coilly A, Sebagh M, Taupin JL, Ibrahim W, Sacleux SC, Ichai P, Duhaut L, Pittau G, Ciacio O, Salloum C, Sa-Cunha A, Azoulay D, Feray C, Cherqui D, Shiha G, Samuel D, Saliba F. Induction with anti-T-lymphocyte globulins and human immunoglobulins: A strategy for hyperimmunized liver transplant patients. World J Hepatol 2026; 18(3): 115221 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i3/115221.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i3.115221 |
