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Publication Name World Journal of Gastroenterology
Manuscript ID 115234
Country China
Received
2025-10-14 05:44
Peer-Review Started
2025-10-14 05:44
First Decision by Editorial Office Director
2025-11-06 09:36
Return for Revision
2025-11-06 09:36
Revised
2025-11-10 14:56
Publication Fee Transferred
Second Decision by Editor
2025-12-24 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-24 10:50
Articles in Press
2025-12-24 10:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-27 11:10
Publish the Manuscript Online
2026-02-06 08:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Study on the mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Kai-Rui Wan, Cheng Qian and Li-Mei Liu
ORCID
Author(s) ORCID Number
Kai-Rui Wan http://orcid.org/0000-0001-5991-5334
Cheng Qian http://orcid.org/0000-0003-1500-9991
Li-Mei Liu http://orcid.org/0009-0004-7014-0831
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Sciences Foundation of China 82273071
Corresponding Author Li-Mei Liu, Associate Professor, MD, PhD, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, No. 131 Yubei Road, Shapingba District, Chongqing 400030, China. limeilliu@126.com
Key Words Hepatitis C virus; Liver cirrhosis; Hepatocellular carcinoma; Estrogen receptor; Tumor necrosis factor-alpha; Sex difference
Core Tip The study by Groover et al is the first to systematically analyze the expression differences and sex-specific correlations of estrogen receptor subtypes and tumor necrosis factor-alpha in the livers of healthy individuals and patients with hepatitis C virus (HCV)-related liver diseases. The study confirms that the expression changes of estrogen receptor β and tumor necrosis factor-alpha are important factors involved in HCV-mediated progression of liver cirrhosis and hepatocellular carcinoma, and sex-specific molecular regulation may be a key mechanism underlying the prognostic differences of HCV-related diseases.
Publish Date 2026-02-06 08:53
Citation

Wan KR, Qian C, Liu LM. Study on the mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 2026; 32(7): 115234

URL https://www.wjgnet.com/1007-9327/full/v32/i7/115234.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i7.115234
Full Article (PDF) WJG-32-115234-with-cover.pdf
Manuscript File 115234_Auto_Edited_024719.docx
Answering Reviewers 115234-answering-reviewers.pdf
Audio Core Tip 115234-audio.mp3
Conflict-of-Interest Disclosure Form 115234-conflict-of-interest-statement.pdf
Copyright License Agreement 115234-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115234-non-native-speakers.pdf
Peer-review Report 115234-peer-reviews.pdf
Scientific Misconduct Check 115234-scientific-misconduct-check.png
Scientific Editor Work List 115234-scientific-editor-work-list.pdf
CrossCheck Report 115234-crosscheck-report.pdf