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Articles Published Processes
2/27/2026 8:35:11 AM | Browse: 1 | Download: 0
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Received |
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2025-10-15 02:19 |
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Peer-Review Started |
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2025-10-15 02:19 |
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First Decision by Editorial Office Director |
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2025-11-18 10:53 |
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Return for Revision |
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2025-11-18 10:53 |
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Revised |
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2025-11-22 08:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-04 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 06:49 |
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Articles in Press |
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2026-01-04 06:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-09 00:51 |
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Publish the Manuscript Online |
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2026-02-27 08:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Han-Ying Huang and Lin Tian |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82173278 |
| National Natural Science Foundation of China |
No. 82573221 |
| Young Talents Program of SYSUCC |
No. YTP-SYSUCC-0045 |
| Fostering Program for NSFC Young Applicants (Tulip Talent Training Program) of SYSUCC |
No. TTP-SYSUCC-202406 |
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| Corresponding Author |
Lin Tian, Assistant Professor, Principal Investigator, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangdong Provincial Clinical Research Center for Cancer, 651 Dongfeng East Road, Guangzhou 500060, Guangdong Province, China. tianlin@sysucc.org.cn |
| Key Words |
Growth differentiation factor 11; Hepatocellular carcinoma; Tumor-associated macrophage; M1/M2 polarization; Cancer invasion |
| Core Tip |
This preview summarizes the dual function of Growth Differentiation Factor 11 (GDF11) as a novel strategy against hepatocellular carcinoma. Beyond suppressing cancer cells, GDF11 uniquely "re-educates" pro-tumoral M2 macrophages – a key driver of immunosuppression. It reprograms these cells by reducing the immunosuppressive marker CD206, rewiring their metabolism, and boosting reactive oxygen species. This shifts the macrophages to an anti-tumor state, neutralizing their cancer-promoting effects. By simultaneously targeting the tumor and its microenvironment, GDF11 offers a novel approach to break immunotherapy resistance, positioning it as a promising candidate for future combination therapies. |
| Publish Date |
2026-02-27 08:35 |
| Citation |
Huang HY, Tian L. Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11. World J Gastroenterol 2026; 32(9): 115259 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i9/115259.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i9.115259 |
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