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Publication Name World Journal of Methodology
Manuscript ID 115265
Country Italy
Received
2025-10-15 02:21
Peer-Review Started
2025-10-15 02:21
First Decision by Editorial Office Director
2025-11-10 07:11
Return for Revision
2025-11-10 07:11
Revised
2025-11-12 06:59
Publication Fee Transferred
Second Decision by Editor
2026-01-21 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-21 08:41
Articles in Press
2026-01-21 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-29 03:06
Publish the Manuscript Online
2026-07-10 10:11
ISSN 2222-0682 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Ophthalmology
Manuscript Type Opinion Review
Article Title Artificial intelligence in ophthalmology: From diagnostic accuracy to clinical application
Manuscript Source Invited Manuscript
All Author List Marco Zeppieri, Matteo Capobianco, Federico Visalli, Marieme Khouyyi, Mutali Musa, Alessandro Avitabile, Inferrera Leandro, Rosa Giglio, Daniele Tognetto, Caterina Gagliano, Fabiana D’Esposito and Francesco Cappellani
ORCID
Author(s) ORCID Number
Marco Zeppieri http://orcid.org/0000-0003-0999-5545
Mutali Musa http://orcid.org/0000-0001-7486-8361
Daniele Tognetto http://orcid.org/0000-0001-7197-7765
Caterina Gagliano http://orcid.org/0000-0001-8424-0068
Fabiana D’Esposito http://orcid.org/0000-0002-7938-876X
Funding Agency and Grant Number
Corresponding Author Caterina Gagliano, MD, PhD, Department of Medicine and Surgery, Kore University of Enna, Viale delle Olimpiadi 1, Enna 94100, Italy. caterina.gagliano@unikore.it
Key Words Ophthalmology; Artificial intelligence; Image classification; Diagnostic precision; Clinical validation
Core Tip Artificial intelligence offers potential for enhancing ocular diagnoses; nevertheless, greater algorithmic accuracy at the image level rarely translates to improved patient outcomes. Obstacles, including data bias, domain shift, and label noise, coupled with a scarcity of prospective research and a lack of cost-effectiveness or equity evaluations, impede translation. Enhancing external validation, establishing predetermined thresholds, and incorporating human-factors engineering into healthcare workflows are imperative. Bridging this gap could convert algorithmic accuracy into significant diagnostic precision for glaucoma, diabetic retinopathy, and macular conditions.
Publish Date 2026-07-10 10:11
Citation

Zeppieri M, Capobianco M, Visalli F, Khouyyi M, Musa M, Avitabile A, Leandro I, Giglio R, Tognetto D, Gagliano C, D’Esposito F, Cappellani F. Artificial intelligence in ophthalmology: From diagnostic accuracy to clinical application. World J Methodol 2026; 16(3): 115265

URL https://www.wjgnet.com/2222-0682/full/v16/i3/115265.htm
DOI https://doi.org/10.5662/wjm.115265
Full Article (PDF) WJM-16-115265-with-cover.pdf
Manuscript File 115265_Auto_Edited_022216-YJP.docx
Answering Reviewers 115265-answering-reviewers.pdf
Audio Core Tip 115265-audio.m4a
Conflict-of-Interest Disclosure Form 115265-conflict-of-interest-statement.pdf
Copyright License Agreement 115265-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115265-non-native-speakers.pdf
Peer-review Report 115265-peer-reviews.pdf
Scientific Misconduct Check 115265-scientific-misconduct-check.png
Scientific Editor Work List 115265-scientific-editor-work-list.pdf
CrossCheck Report 115265-crosscheck-report.pdf