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Articles Published Processes
5/13/2026 8:18:29 AM | Browse: 1 | Download: 14
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Received |
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2025-10-15 02:48 |
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Peer-Review Started |
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2025-10-15 02:48 |
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First Decision by Editorial Office Director |
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2025-11-11 08:41 |
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Return for Revision |
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2025-11-11 08:41 |
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Revised |
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2025-12-02 06:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-03 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-03 07:40 |
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Articles in Press |
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2026-02-03 07:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-16 09:35 |
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Publish the Manuscript Online |
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2026-05-13 08:18 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0 |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology, Clinical |
| Manuscript Type |
Observational Study |
| Article Title |
Linkage of kynurenine pathway metabolites to neuroinflammation in drug-naive children with attention-deficit/hyperactivity disorder: A cross-sectional, case–control study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kübranur Ünal, Yasemin Taş Torun, Mehmet Emre Erol, Cansu Özbaş and Zeynep Kübra Kurt |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kübranur Ünal, Associate Professor, MD, Department of Medical Biochemistry, Gazi University, Faculty of Medicine, Emniyet, Gazi Hst., Yenimahalle, Ankara 06560, Türkiye. kubranurunal@gazi.edu.tr |
| Key Words |
Attention deficit hyperactivity disorder; Kynurenine; Kynurenine pathway; Neuroinflammation; Tryptophan metabolism alterations |
| Core Tip |
This study examined the kynurenine pathway (KP) in medication-naive children with attention-deficit/hyperactivity disorder (ADHD), focusing on the balance between neuroprotective and neurotoxic metabolites. Serum kynurenic acid (KYNA) levels and the KYNA/quinolinic acid ratio were significantly lower in ADHD patients, while the neurotoxic quinolinic acid/KYNA ratio was higher compared to controls. These findings suggest an imbalance between excitotoxic and neuroprotective mechanisms and suggest that dysregulation of the KP may play a role in the pathophysiology of ADHD. Although diagnostic accuracy is low, the results highlight the potential of KP-derived indices as biomarkers of ADHD. Larger longitudinal studies will be necessary to determine causal relationships and assess the therapeutic modulation of KP activity. |
| Publish Date |
2026-05-13 08:18 |
| Citation |
Ünal K, Taş Torun Y, Erol ME, Özbaş C, Kurt ZK. Linkage of kynurenine pathway metabolites to neuroinflammation in drug-naive children with attention-deficit/hyperactivity disorder: A cross-sectional, case–control study. World J Clin Pediatr 2026; 15(2): 115284 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i2/115284.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i2.115284 |
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